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Protein Domain : IPR019801

Name  Glycoside hydrolase, family 35, conserved site Short Name  Glyco_hydro_35_CS
Type  Conserved_site Description  O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 35 comprises enzymes with only one known activity; beta-galactosidase ().Mammalian beta-galactosidase is a lysosomal enzyme (gene GLB1) which cleaves the terminal galactose from gangliosides, glycoproteins, and glycosaminoglycans and whose deficiency is the cause of the genetic disease Gm(1) gangliosidosis (Morquio disease type B).One of the best conserved regions in these enzymes contains a glutamic acid residue which, on the basis of similarities with other families of glycosyl hydrolases, probably acts as the proton donor in the catalytic mechanism. This signature spans the region contain the putative active site glutamic acid residue, it is the second glutamic acid residue of the two in the pattern [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS01182 PROSITE IPR019801

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

3 Found In

DB identifier Name Short Name Type
IPR013781 Glycoside hydrolase, catalytic domain Glyco_hydro_catalytic_dom Domain
IPR017853 Glycoside hydrolase, superfamily Glycoside_hydrolase_SF Domain
IPR001944 Glycoside hydrolase, family 35 Glycoside_Hdrlase_35 Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Glycoside hydrolase, family 35, conserved site   GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Glycoside hydrolase, family 35, conserved site   GO:0005975 carbohydrate metabolic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Glycoside hydrolase, family 35, conserved site   GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Glycoside hydrolase, family 35, conserved site   GO:0005975 carbohydrate metabolic process

0 Parent Features

11 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081961 Q9VGE7 Drosophila melanogaster
FBpp0284521 Q295T2 Drosophila pseudoobscura
FBpp0172769 B4K5L9 Drosophila mojavensis
FBpp0237948 B4LWG7 Drosophila virilis
FBpp0271164 B4PN17 Drosophila yakuba
A8Y4M0_CAEBR A8Y4M0 Caenorhabditis briggsae
H2VLF0_CAEJA H2VLF0 Caenorhabditis japonica
G0N8L3_CAEBE G0N8L3 Caenorhabditis brenneri
G0PJA7_CAEBE G0PJA7 Caenorhabditis brenneri
Q27526_CAEEL Q27526 Caenorhabditis elegans
E3NKR3_CAERE E3NKR3 Caenorhabditis remanei