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Protein Domain : IPR016343

Name  Spectrin, beta subunit Short Name  Spectrin_bsu
Type  Family Description  Spectrins are involved in the support of general membrane integrity, stabilisation of cell-cell interactions, axonal growth, normal functioning of the Golgi complex and organisation of synaptic vesicles [, , ]. Spectrin is a tetrameric actin cross-linking protein, which contains two alpha and two beta subunits. Two genes for alpha-spectrin [, , ]and five for beta-spectrin have been identified in both mice and humans, each of which is alternatively spliced to produce multiple spectrin isoforms [, ]. Beta-spectrins are more diverse than alpha-spectrin, and include mammalian erythrocytic beta-spectrin, non-erythroid beta-spectrin/Fodrin (beta-G, the general form of beta-spectrin expressed in multiple tissues), a novel beta-G spectrin (ELF1-4) that lacks the C-terminal PH (pleckstrin homology) domain, the brain-specific SPTBN2, and beta-V spectrin.ELF (), a modulator of the Smad adaptor proteins involved in the TGF-beta signalling pathway, was originally identified from endodermal stem/progenitor cells committed to foregut lineage [, ]. ELF is a beta-spectrin that is important for distinct functional membrane generation, protein sorting, cell adhesion and the development of a polarized differentiated epithelial cell [, ]. ELF-deficient mice display disruption of transforming growth factor-beta (TGF-beta) signalling by Smad proteins []. Evidence from null mutants of ELF confirms that ELF is a novel beta-G spectrin and not an isoform of beta-spectrins []. ELF is ubiquitinated by PRAJA, a RING finger protein (). Aberrations in Elf's involvement in Smad4 localization and subsequent activation of Smad4 could result in tumourigenesis.

Publication Counts Displayer

0 Child Features

6 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR001715 Calponin homology domain CH-domain Domain
IPR001589 Actinin-type, actin-binding, conserved site Actinin_actin-bd_CS Conserved_site
IPR001605 Pleckstrin homology domain, spectrin-type PH_dom-spectrin-type Domain
IPR018159 Spectrin/alpha-actinin Spectrin/alpha-actinin Repeat
IPR002017 Spectrin repeat Spectrin_repeat Repeat

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF002297 PIRSF IPR016343

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Spectrin, beta subunit   GO:0003779 actin binding
Spectrin, beta subunit   GO:0005200 structural constituent of cytoskeleton
Spectrin, beta subunit   GO:0008091 spectrin

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Spectrin, beta subunit   GO:0003779 actin binding
Spectrin, beta subunit   GO:0005200 structural constituent of cytoskeleton
Spectrin, beta subunit   GO:0008091 spectrin

0 Parent Features

14 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074228 Q00963 Drosophila melanogaster
FBpp0306507 M9PF16 Drosophila melanogaster
FBpp0306508 M9PHG4 Drosophila melanogaster
FBpp0273248 Q29JE1 Drosophila pseudoobscura
FBpp0165522 B4L653 Drosophila mojavensis
FBpp0230058 B4MAL4 Drosophila virilis
FBpp0262686 B4Q2I9 Drosophila yakuba
A8XUM5_CAEBR A8XUM5 Caenorhabditis briggsae
G0MY27_CAEBE G0MY27 Caenorhabditis brenneri
Q9U9J8_CAEEL Q9U9J8 Caenorhabditis elegans
G5EG85_CAEEL G5EG85 Caenorhabditis elegans
S6FN00_CAEEL S6FN00 Caenorhabditis elegans
E0AHA7_CAEEL E0AHA7 Caenorhabditis elegans
E3LPH0_CAERE E3LPH0 Caenorhabditis remanei