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Protein Domain : IPR001944

Name  Glycoside hydrolase, family 35 Short Name  Glycoside_Hdrlase_35
Type  Family Description  O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 35 comprises enzymes with only one known activity; beta-galactosidase ().Mammalian beta-galactosidase is a lysosomal enzyme (gene GLB1) which cleaves the terminal galactose from gangliosides, glycoproteins, and glycosaminoglycans and whose deficiency is the cause of the genetic disease Gm(1) gangliosidosis (Morquio disease type B).

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR026283 Beta-galactosidase 1-like B-gal_1-like Family

4 Contains

DB identifier Name Short Name Type
IPR008979 Galactose-binding domain-like Galactose-bd-like Domain
IPR013781 Glycoside hydrolase, catalytic domain Glyco_hydro_catalytic_dom Domain
IPR019801 Glycoside hydrolase, family 35, conserved site Glyco_hydro_35_CS Conserved_site
IPR018954 Beta-galactosidase, domain 2 Betagal_dom2 Domain

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR23421 PANTHER IPR001944
PF01301 PFAM IPR001944
PR00742 PRINTS IPR001944

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Glycoside hydrolase, family 35   GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Glycoside hydrolase, family 35   GO:0005975 carbohydrate metabolic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Glycoside hydrolase, family 35   GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Glycoside hydrolase, family 35   GO:0005975 carbohydrate metabolic process

0 Parent Features

22 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0078861 Q9VMJ5 Drosophila melanogaster
FBpp0081961 Q9VGE7 Drosophila melanogaster
FBpp0304852 M9PCA6 Drosophila melanogaster
FBpp0279224 B5DH41 Drosophila pseudoobscura
FBpp0284521 Q295T2 Drosophila pseudoobscura
FBpp0160512 B4KGG7 Drosophila mojavensis
FBpp0172769 B4K5L9 Drosophila mojavensis
FBpp0226942 B4LR78 Drosophila virilis
FBpp0237948 B4LWG7 Drosophila virilis
FBpp0263971 B4NZS4 Drosophila yakuba
FBpp0271164 B4PN17 Drosophila yakuba
A8XC77_CAEBR A8XC77 Caenorhabditis briggsae
A8Y4M0_CAEBR A8Y4M0 Caenorhabditis briggsae
H2VLF0_CAEJA H2VLF0 Caenorhabditis japonica
H2VWB6_CAEJA H2VWB6 Caenorhabditis japonica
G0N8L3_CAEBE G0N8L3 Caenorhabditis brenneri
G0PJA7_CAEBE G0PJA7 Caenorhabditis brenneri
G0MSH6_CAEBE G0MSH6 Caenorhabditis brenneri
Q27526_CAEEL Q27526 Caenorhabditis elegans
O76632_CAEEL O76632 Caenorhabditis elegans
E3NKR3_CAERE E3NKR3 Caenorhabditis remanei
E3LDC1_CAERE E3LDC1 Caenorhabditis remanei