modENCODE |  Help |  blog

Protein Domain : IPR018826

Name  WW-domain-binding protein Short Name  WW-domain-binding
Type  Domain Description  This entry represents a sequence domain found in WW domain-binding protein that is characterised by several short PY and PT-like motifs of the PPPPY form. These appear to bind directly to the WW domains of WWP1 and WWP2 and other such diverse proteins as dystrophin and YAP (Yes-associated protein). The presence of a phosphotyrosine residue in the pWBP-1 peptide abolishes WW domain binding which suggests a potential regulatory role for tyrosine phosphorylation in modulating WW domain-ligand interactions. Given the likelihood that WWP1 and WWP2 function as E3 ubiquitin-protein ligases, it is possible that initial substrate-specific recognition occurs via WW domain-substrate protein interaction followed by ubiquitin transfer and subsequent proteolysis []. This domain lies just downstream of in many sequences.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF10349 PFAM IPR018826

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

19 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0271749 Q95SE8 Drosophila melanogaster
FBpp0304357 M9PFH0 Drosophila melanogaster
FBpp0304358 F0JAQ9 Drosophila melanogaster
FBpp0304356 Q9VU19 Drosophila melanogaster
FBpp0304355 M9PF27 Drosophila melanogaster
FBpp0274072 Q2LYX3 Drosophila pseudoobscura
FBpp0160884 B4L0T6 Drosophila mojavensis
FBpp0225762 B4LBI9 Drosophila virilis
FBpp0266938 B4PGV8 Drosophila yakuba
A8XJL0_CAEBR A8XJL0 Caenorhabditis briggsae
A8XXC3_CAEBR A8XXC3 Caenorhabditis briggsae
H2W3Q3_CAEJA H2W3Q3 Caenorhabditis japonica
H2WS72_CAEJA H2WS72 Caenorhabditis japonica
G0M7Q7_CAEBE G0M7Q7 Caenorhabditis brenneri
G0NEA3_CAEBE G0NEA3 Caenorhabditis brenneri
Q18075_CAEEL Q18075 Caenorhabditis elegans
Q18966_CAEEL Q18966 Caenorhabditis elegans
E3N381_CAERE E3N381 Caenorhabditis remanei
E3LEV0_CAERE E3LEV0 Caenorhabditis remanei