modENCODE |  Help |  blog

Protein Domain : IPR015767

Name  Rho GTPase activating protein Short Name  Rho_GTPase_act
Type  Family Description  Members of Rho are small G proteins that transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs), which stimulate the intrinsic GTPase activity of small G proteins. This entry is a Rho/Rac/Cdc42-like GAP domain which is found in a wide variety of large, multi-functional proteins []. A number of structures are known [, , ]. The domain is composed of seven alpha-helices. This domain is also known as the breakpoint cluster region-homology (BH) domain.RhoGAP is widely evolutionarily conserved from Saccharomyces cerevisiae(Baker's yeast) to Homo sapiens(Human).

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR001849 Pleckstrin homology domain Pleckstrin_homology Domain
IPR000198 Rho GTPase-activating protein domain RhoGAP_dom Domain

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

16 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074287 Q9VWY8 Drosophila melanogaster
FBpp0272058 B5DMV9 Drosophila pseudoobscura
FBpp0164394 B4L2I1 Drosophila mojavensis
FBpp0231474 B4M7V7 Drosophila virilis
FBpp0262718 B4Q2N7 Drosophila yakuba
A8XSR0_CAEBR A8XSR0 Caenorhabditis briggsae
K7HT29_CAEJA K7HT29 Caenorhabditis japonica
K7GYZ5_CAEJA K7GYZ5 Caenorhabditis japonica
H2WW37_CAEJA H2WW37 Caenorhabditis japonica
K7GYZ4_CAEJA K7GYZ4 Caenorhabditis japonica
K7HT28_CAEJA K7HT28 Caenorhabditis japonica
G0MEG3_CAEBE G0MEG3 Caenorhabditis brenneri
TG325_CAEEL P46941 Caenorhabditis elegans
A9UND9_DROME A9UND9 Drosophila melanogaster
Q960F5_DROME Q960F5 Drosophila melanogaster
E3MCR8_CAERE E3MCR8 Caenorhabditis remanei