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Protein Domain : IPR000034

Name  Laminin B type IV Short Name  Laminin_B_type_IV
Type  Domain Description  Laminins represent a distinct family of extracellular matrix proteins present only in basement membranes in almost every animal tissue. They are heterotrimeric molecules composed of alpha, beta and gamma subunits (formerly A, B1, and B2, respectively []) and form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains, [, ]. Most of the globular domains of the short arms correspond to one of two different motifs, the 200-residue laminin N-terminal (domain VI) (LN) module and the 250-residue laminin domain IV (L4) module []. All alpha chains share a unique C-terminal G domain which consists of five laminin G modules. The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. There are at least 14 laminin isoforms that regulate a variety of cellular functions including cell adhesion, migration, proliferation, signalling and differentiation [, , ].The laminin B domain (also known as domain IV) is an extracellular module of unknown function. It is found in a number of different proteins that include, heparan sulphate proteoglycan from basement membrane, a laminin-like protein from Caenorhabditis elegansand laminin. Laminin IV domain is not found in short laminin chains (alpha4 or beta3).

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR018031 Laminin B, subgroup Laminin_B_subgr Domain

0 Contains

2 Cross References

Source . Name

Subject . Primary Identifier
PF00052 PFAM IPR000034
PS51115 PROFILE IPR000034

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

77 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0291871 Q8IP51 Drosophila melanogaster
FBpp0293600 R9PY40 Drosophila melanogaster
FBpp0291872 M9MRU0 Drosophila melanogaster
FBpp0076111 P15215 Drosophila melanogaster
FBpp0309651 M9NDM1 Drosophila melanogaster
FBpp0309652 M9NFS1 Drosophila melanogaster
FBpp0309653 M9NE61 Drosophila melanogaster
FBpp0309655 Q9W4Y3 Drosophila melanogaster
FBpp0309648 M9NGL3 Drosophila melanogaster
FBpp0309649 Q9W4Y4 Drosophila melanogaster
FBpp0309650 Q8IRV8 Drosophila melanogaster
FBpp0309660 M9NFR6 Drosophila melanogaster
FBpp0309661 A0A023GRW4 Drosophila melanogaster
FBpp0309656 M9NES6 Drosophila melanogaster
FBpp0309658 Q8IRV9 Drosophila melanogaster
FBpp0309646 M9NE56 Drosophila melanogaster
FBpp0309644 E1JJC0 Drosophila melanogaster
FBpp0309647 M9NGK3 Drosophila melanogaster
FBpp0309645 M9NET2 Drosophila melanogaster
FBpp0309641 Q8MPN3 Drosophila melanogaster
FBpp0309643 Q8IRV7 Drosophila melanogaster
FBpp0309642 M9NDL5 Drosophila melanogaster
FBpp0272120 Q29FR2 Drosophila pseudoobscura
FBpp0277205 Q29FI3 Drosophila pseudoobscura
FBpp0287175 Q29CY8 Drosophila pseudoobscura
FBpp0287348 Q29KB2 Drosophila pseudoobscura
FBpp0162030 B4KEJ3 Drosophila mojavensis
FBpp0162448 B4KVQ7 Drosophila mojavensis
FBpp0162469 B4KVT7 Drosophila mojavensis
FBpp0165110 B4L1X8 Drosophila mojavensis