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Protein Domain : IPR020550

Name  Inositol monophosphatase, conserved site Short Name  Inositol_monophosphatase_CS
Type  Conserved_site Description  It has been shown that several proteins share two sequence motifs []. Two of theseproteins, vertebrate and plant inositol monophosphatase (), and vertebrate inositolpolyphosphate 1-phosphatase (), are enzymes of the inositol phosphate second messengersignalling pathway, and share similar enzyme activity. Both enzymes exhibit an absolute requirementfor metal ions (Mg2+is preferred), and their amino acid sequences contain a number of conservedmotifs, which are also shared by several other proteins related to MPTASE (including products of fungal QaX and qutG, bacterial suhB and cysQ, and yeast hal2) []. The function of theother proteins is not yet clear, but it is suggested that they may act by enhancing the synthesisor degradation of phosphorylated messenger molecules []. Structural analysis of theseproteins has revealed a common core of 155 residues, which includes residues essential for metalbinding and catalysis. An interesting property of the enzymes of this family is their sensitivityto Li+. The targets and mechanism of action of Li+are unknown, but overactive inositol phosphatesignalling may account for symptoms of manic depression [].This entry represents a conserved signature pattern found within the inositol monophosphatase family of proteins. It is suggested []that these proteins may act by enhancing the synthesis or degradation of phosphorylated messenger molecules.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00630 PROSITE IPR020550

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR000760 Inositol monophosphatase Inositol_monophosphatase Family
IPR020552 Inositol monophosphatase, Lithium-sensitive Inositol_monoPase_Li-sen Family
IPR006239 3(2),5 -bisphosphate nucleotidase HAL2 Bisphos_HAL2 Family
IPR006240 3(2),5 -bisphosphate nucleotidase, bacterial Bisphos_bac Family
IPR022337 Inositol monophosphatase, SuhB Inositol_monophosphatase_SuhB Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Inositol monophosphatase, conserved site   GO:0046854 phosphatidylinositol phosphorylation

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Inositol monophosphatase, conserved site   GO:0046854 phosphatidylinositol phosphorylation

0 Parent Features

68 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075270 Q9VUW3 Drosophila melanogaster
FBpp0073586 Q9VYF2 Drosophila melanogaster
FBpp0075271 Q9VUW4 Drosophila melanogaster
FBpp0075269 Q9VUW2 Drosophila melanogaster
FBpp0082328 Q9VFP6 Drosophila melanogaster
FBpp0078069 Q9VP62 Drosophila melanogaster
FBpp0084849 Q9VAG9 Drosophila melanogaster
FBpp0075268 Q9VUW1 Drosophila melanogaster
FBpp0078071 Q7KTW5 Drosophila melanogaster
FBpp0284119 Q297T3 Drosophila pseudoobscura
FBpp0274009 B5DQB3 Drosophila pseudoobscura
FBpp0282077 Q298W0 Drosophila pseudoobscura
FBpp0286027 Q29D88 Drosophila pseudoobscura
FBpp0286028 Q29D89 Drosophila pseudoobscura
FBpp0286031 B5DRX0 Drosophila pseudoobscura
FBpp0286032 Q29D90 Drosophila pseudoobscura
FBpp0159262 B4K9B2 Drosophila mojavensis
FBpp0161095 B4KYI3 Drosophila mojavensis
FBpp0161093 B4KYI5 Drosophila mojavensis
FBpp0161094 B4KYI4 Drosophila mojavensis
FBpp0161097 B4KYI2 Drosophila mojavensis
FBpp0161418 B4KUM3 Drosophila mojavensis
FBpp0161420 B4KUM1 Drosophila mojavensis
FBpp0170679 B4L5T3 Drosophila mojavensis
FBpp0171261 B4KAN4 Drosophila mojavensis
FBpp0225850 B4LHB3 Drosophila virilis
FBpp0225851 B4LHB2 Drosophila virilis
FBpp0225852 B4LHB1 Drosophila virilis
FBpp0225853 B4LHB0 Drosophila virilis
FBpp0227989 B4LDZ2 Drosophila virilis