modENCODE |  Help |  blog

Protein Domain : IPR000917

Name  Sulfatase Short Name  Sulfatase
Type  Domain Description  Sulphatases are enzymes that hydrolyze various sulphate esters. The sequence of different types of sulphatases are available and have shown to be structurally related [, , ]; these include:arylsulphatase A (ASA), a lysosomal enzyme which hydrolyses cerebroside sulphate; arylsulphatase B (ASB), which hydrolyses the sulphate ester group from N-acetylgalactosamine 4-sulphate residues of dermatan sulphate; arylsulphatase C (ASD) and E (ASE);steryl-sulphatase (STS), a membrane bound microsomal enzyme which hydrolyses 3-beta-hydroxy steroid sulphates;iduronate 2-sulphatase precursor (IDS), a lysosomal enzyme that hydrolyses the 2-sulphate groups from non-reducing-terminal iduronic acid residues in dermatan sulphate and heparan sulphate;N-acetylgalactosamine-6-sulphatase , which hydrolyses the 6-sulphate groups of the N-acetyl-d-galactosamine 6-sulphate units of chondroitin sulphate and the D-galactose 6-sulphate units of keratan sulphate;glucosamine-6-sulphatase (G6S), which hydrolyses the N-acetyl-D-glucosamine 6-sulphate units of heparan sulphate and keratan sulphate;N-sulphoglucosamine sulphohydrolase (sulphamidase), the lysosomal enzyme that catalyses the hydrolysis of N-sulpho-d-glucosamine into glucosamine and sulphate;sea urchin embryo arylsulphatase ;green algae arylsulphatase , which plays an important role in the mineralisation of sulphates;and arylsulphatase from Escherichia coli(aslA), Klebsiella aerogenes(gene atsA) and Pseudomonas aeruginosa(gene atsA).

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha Alkaline_Pase-like_a/b/a Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00884 PFAM IPR000917

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

8 Found In

DB identifier Name Short Name Type
IPR012251 N-acetylglucosamine-6-sulfatase GlcNAc_6-SO4ase Family
IPR020881 Phosphoglycerol transferase I Phosphoglycerol_transferase_I Family
IPR015981 N-acetylglucosamine-6-sulfatase, eukaryotic GlcNAc_6-SO4ase_euk Family
IPR017785 Choline-sulfatase Choline-sulfatase Family
IPR014615 Extracellular sulfatase Extracellular_sulfatase Family
IPR012083 Arylsulfatase Arylsulfatase Family
IPR012159 Membrane sulfatase, HI0842-related Membrane_sulfatase_HI0842 Family
IPR012160 Membrane sulfatase, HI1246-related Membrane_sulfatase_HI1246 Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Sulfatase   GO:0008484 sulfuric ester hydrolase activity
Sulfatase   GO:0008152 metabolic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Sulfatase   GO:0008484 sulfuric ester hydrolase activity
Sulfatase   GO:0008152 metabolic process

1 Parent Features

DB identifier Name Short Name Type
IPR017850 Alkaline-phosphatase-like, core domain Alkaline_phosphatase_core Domain

65 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086833 Q5BIL9 Drosophila melanogaster
FBpp0074908 Q9VVM1 Drosophila melanogaster
FBpp0083138 Q9VE24 Drosophila melanogaster
FBpp0072939 Q9VZP8 Drosophila melanogaster
FBpp0074909 Q9VVM4 Drosophila melanogaster
FBpp0082725 Q9VEX0 Drosophila melanogaster
FBpp0086832 Q95R73 Drosophila melanogaster
FBpp0290455 Q8SZ72 Drosophila melanogaster
FBpp0300164 Q8IQS4 Drosophila melanogaster
FBpp0281961 Q298E8 Drosophila pseudoobscura
FBpp0275451 B5DQ67 Drosophila pseudoobscura
FBpp0274127 Q2LZ24 Drosophila pseudoobscura
FBpp0275452 B5DQ69 Drosophila pseudoobscura
FBpp0277252 Q293E6 Drosophila pseudoobscura
FBpp0284513 Q295V0 Drosophila pseudoobscura
FBpp0286980 Q29DQ4 Drosophila pseudoobscura
FBpp0307281 B5E066 Drosophila pseudoobscura
FBpp0161597 B4KZK8 Drosophila mojavensis
FBpp0162832 B4L0G6 Drosophila mojavensis
FBpp0163236 B4L7H5 Drosophila mojavensis
FBpp0167704 B4KSP7 Drosophila mojavensis
FBpp0173840 B4K587 Drosophila mojavensis
FBpp0173869 B4K5S3 Drosophila mojavensis
FBpp0226687 B4LF09 Drosophila virilis
FBpp0228369 B4LIG2 Drosophila virilis
FBpp0228602 Q8I189 Drosophila virilis
FBpp0234208 B4MGI5 Drosophila virilis
FBpp0234242 B4MGL0 Drosophila virilis
FBpp0235766 B4LP85 Drosophila virilis
FBpp0237922 B4LWU0 Drosophila virilis