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Protein Domain : IPR001762

Name  Blood coagulation inhibitor, Disintegrin Short Name  Blood-coag_inhib_Disintegrin
Type  Domain Description  Disintegrins are a family of small proteins from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion [, ]. Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. Disintegrins act as receptor antagonists, inhibiting aggregation induced by ADP, thrombin, platelet-activating factor and collagen []. The role of disintegrin in preventing blood coagulation renders it of medical interest, particularly with regard to its use as an anti-coagulant [].Disintegrins from different snake species have been characterised: albolabrin, applagin, barbourin, batroxostatin, bitistatin, obtustatin [], schistatin [], echistatin [], elegantin, eristicophin, flavoridin [], halysin, kistrin, tergeminin, salmosin []and triflavin.Disintegrin-like proteins are found in various species ranging from slime mold to humans. Some other proteins known to contain a disintegrin domain are:Some snake venom zinc metalloproteinases []consist of an N-terminal catalytic domain fused to a disintegrin domain. Such is the case for trimerelysin I (HR1B), atrolysin-e (Ht-e) and trigramin. It has been suggested that these proteinases are able to cleave themselves from the disintegrin domains and that the latter may arise from such a post-translational processing.The beta-subunit of guinea pig sperm surface protein PH30 []. PH30 is a protein involved in sperm-egg fusion. The beta subunit contains a disintegrin at the N-terminal extremity.Mammalian epididymial apical protein 1 (EAP I) []. EAP I is associated with the sperm membrane and may play a role in sperm maturation. Structurally, EAP I consists of an N-terminal domain, followed by a zinc metalloproteinase domain, a disintegrin domain, and a large C-terminal domain that contains a transmembrane region.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR018358 Disintegrin, conserved site Disintegrin_CS Conserved_site

6 Cross References

Source . Name

Subject . Primary Identifier
PF00200 PFAM IPR001762
PR00289 PRINTS IPR001762
PS50214 PROFILE IPR001762
SM00050 SMART IPR001762
SSF57552 SSF IPR001762

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

59 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0084826 Q9VAI2 Drosophila melanogaster
FBpp0084917 Q9VAC5 Drosophila melanogaster
FBpp0100122 Q59DZ3 Drosophila melanogaster
FBpp0080087 Q9VJW9 Drosophila melanogaster
FBpp0300197 M9NDY9 Drosophila melanogaster
FBpp0288809 Q7KUY7 Drosophila melanogaster
FBpp0288810 B7Z0Y2 Drosophila melanogaster
FBpp0309702 A8DZ03 Drosophila melanogaster
FBpp0290713 Q6QU65 Drosophila melanogaster
FBpp0290714 Q400M8 Drosophila melanogaster
FBpp0290626 A8DZ02 Drosophila melanogaster
FBpp0301989 M9PER2 Drosophila melanogaster
FBpp0301990 M9PH86 Drosophila melanogaster
FBpp0300195 M9NH46 Drosophila melanogaster
FBpp0300196 Q9VXL1 Drosophila melanogaster
FBpp0279058 Q29PB0 Drosophila pseudoobscura
FBpp0293329 Q29BU0 Drosophila pseudoobscura
FBpp0283737 B5DVG7 Drosophila pseudoobscura
FBpp0283101 B5DXC1 Drosophila pseudoobscura
FBpp0159635 B4K607 Drosophila mojavensis
FBpp0160018 B4KC41 Drosophila mojavensis
FBpp0164159 B4L421 Drosophila mojavensis
FBpp0171294 B4KA39 Drosophila mojavensis
FBpp0225051 B4M5S6 Drosophila virilis
FBpp0228816 B4MBA9 Drosophila virilis
FBpp0233387 B4M3E9 Drosophila virilis
FBpp0232281 B4M9R4 Drosophila virilis
FBpp0237313 B4LXB2 Drosophila virilis
FBpp0255857 B4PL54 Drosophila yakuba
FBpp0261012 B4PXA1 Drosophila yakuba