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Protein Domain : IPR006121

Name  Heavy metal-associated domain, HMA Short Name  HeavyMe-assoc_HMA
Type  Domain Description  Proteins that transport heavy metals in micro-organisms and mammals share similarities in their sequences and structures.These proteins provide an important focus for research, some being involved in bacterial resistance to toxic metals, such as lead and cadmium, while others are involved in inherited human syndromes, such as Wilson's and Menke's diseases []. A conserved domain has been found in a number of these heavy metal transport or detoxification proteins []. The domain, which has been termed Heavy-Metal-Associated (HMA), contains two conserved cysteines that are probably involved in metal binding.Structure solution of the fourth HMA domain of the Menke's copper transportingATPase shows a well-defined structure comprising a four-stranded antiparallelbeta-sheet and two alpha helices packed in an alpha-beta sandwich fold []. This fold is common to other domains and is classifiedas "ferredoxin-like".

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR006122 Heavy metal-associated domain, copper ion-binding HMA_Cu_ion-bd Domain

1 Contains

DB identifier Name Short Name Type
IPR017969 Heavy-metal-associated, conserved site Heavy-metal-associated_CS Conserved_site

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00403 PFAM IPR006121
PS50846 PROFILE IPR006121
SSF55008 SSF IPR006121

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR001757 Cation-transporting P-type ATPase Cation_transp_P_typ_ATPase Family
IPR016617 Uncharacterised conserved protein UCP013899, metal binding UCP013899_metal-bd Family
IPR021179 Mercury reductase, MerA Mercury_reductase_MerA Family
IPR000579 Cation-transporting P-type ATPase A/B Cation-trans_P-type_ATPase_A/B Family
IPR016578 Copper chaperone, chloroplast-targeted, predicted Cu_chp_chlpt-target_pred Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Heavy metal-associated domain, HMA   GO:0046872 metal ion binding
Heavy metal-associated domain, HMA   GO:0030001 metal ion transport

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Heavy metal-associated domain, HMA   GO:0046872 metal ion binding
Heavy metal-associated domain, HMA   GO:0030001 metal ion transport

0 Parent Features

27 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0271765 Q9VYT4 Drosophila melanogaster
FBpp0078080 Q95RR1 Drosophila melanogaster
FBpp0303150 M9PD88 Drosophila melanogaster
FBpp0272696 B5DLH5 Drosophila pseudoobscura
FBpp0274471 Q2M098 Drosophila pseudoobscura
FBpp0160774 B4KV40 Drosophila mojavensis
FBpp0165341 B4L6R5 Drosophila mojavensis
FBpp0169476 B4KNU8 Drosophila mojavensis
FBpp0225652 B4LD95 Drosophila virilis
FBpp0230820 B4M7Q7 Drosophila virilis
FBpp0234629 B4LJV9 Drosophila virilis
FBpp0260680 B4Q1I5 Drosophila yakuba
FBpp0264792 B4PDI9 Drosophila yakuba
A8XZM5_CAEBR A8XZM5 Caenorhabditis briggsae
A8XF35_CAEBR A8XF35 Caenorhabditis briggsae
K7HH65_CAEJA K7HH65 Caenorhabditis japonica
H2VPJ7_CAEJA H2VPJ7 Caenorhabditis japonica
G0MCI1_CAEBE G0MCI1 Caenorhabditis brenneri
G5EE41_CAEEL G5EE41 Caenorhabditis elegans
G5EE14_CAEEL G5EE14 Caenorhabditis elegans
G5ED40_CAEEL G5ED40 Caenorhabditis elegans
O17537_CAEEL O17537 Caenorhabditis elegans
Q6IDF6_DROME Q6IDF6 Drosophila melanogaster
E3NAD9_CAERE E3NAD9 Caenorhabditis remanei
E3NWZ1_CAERE E3NWZ1 Caenorhabditis remanei
E3NAD7_CAERE E3NAD7 Caenorhabditis remanei
E3MKS6_CAERE E3MKS6 Caenorhabditis remanei