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Protein Domain : IPR015788

Name  Moesin/ezrin/radixin homologue 2 Short Name  EMR2
Type  Family Description  This entry represents the moesin/ezrin/radixin homologue 2 (EMR2, also known as Mer). It is a regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, a signalling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. EMR2 acts synergistically along with Ex and Kibra to regulate the Hippo signalling pathway [, ].

Publication Counts Displayer

0 Child Features

9 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle FERM/acyl-CoA-bd_prot_3-hlx Domain
IPR019748 FERM central domain FERM_central Domain
IPR000299 FERM domain FERM_domain Domain
IPR019747 FERM conserved site FERM_CS Conserved_site
IPR018980 FERM, C-terminal PH-like domain FERM_PH-like_C Domain
IPR011259 Ezrin/radixin/moesin, C-terminal ERM_C_dom Domain
IPR008954 Moesin tail domain Moesin_tail Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR23281:SF4 PANTHER IPR015788

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Moesin/ezrin/radixin homologue 2   GO:0008092 cytoskeletal protein binding
Moesin/ezrin/radixin homologue 2   GO:0008285 negative regulation of cell proliferation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Moesin/ezrin/radixin homologue 2   GO:0008092 cytoskeletal protein binding
Moesin/ezrin/radixin homologue 2   GO:0008285 negative regulation of cell proliferation

1 Parent Features

DB identifier Name Short Name Type
IPR011174 Ezrin/radixin/moesin ERM Family

12 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074523 Q24564 Drosophila melanogaster
FBpp0284534 Q29HY4 Drosophila pseudoobscura
FBpp0160236 B4L7Z7 Drosophila mojavensis
FBpp0230035 B4MAR0 Drosophila virilis
FBpp0262370 B4PZD7 Drosophila yakuba
A8XZG8_CAEBR A8XZG8 Caenorhabditis briggsae
H2WBW8_CAEJA H2WBW8 Caenorhabditis japonica
G0N2N7_CAEBE G0N2N7 Caenorhabditis brenneri
H2KYX3_CAEEL H2KYX3 Caenorhabditis elegans
H2KYX2_CAEEL H2KYX2 Caenorhabditis elegans
Q5LK46_CAEEL Q5LK46 Caenorhabditis elegans
E3LWN6_CAERE E3LWN6 Caenorhabditis remanei