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Protein Domain : IPR000266

Name  Ribosomal protein S17 Short Name  Ribosomal_S17
Type  Family Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNAbased, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].The ribosomal proteins catalyse ribosome assembly and stabilise the rRNA, tuning the structure of the ribosome for optimal function. Evidence suggests that, in prokaryotes, the peptidyl transferase reaction is performed by the large subunit 23S rRNA, whereas proteins probably have a greater role in eukaryotic ribosomes. Most of the proteins lie close to, or on the surface of, the 30S subunit, arranged peripherally around the rRNA []. The small subunit ribosomal proteins can be categorised as primary binding proteins, which bind directly and independently to 16S rRNA; secondary binding proteins, which display no specific affinity for 16S rRNA, but its assembly is contingent upon the presence of one or more primary binding proteins; and tertiary binding proteins, which require the presence of one or more secondary binding proteins and sometimes other tertiary binding proteins.The small ribosomal subunit protein S17 is known to bind specifically to the 5' end of 16S ribosomal RNA in Escherichia coli(primary rRNA binding protein), and is thought to be involved in the recognition of termination codons. Experimental evidence []has revealed that S17 has virtually no groups exposed on the ribosomal surface.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR028333 Ribosomal protein S17, archaeal/eukaryotic Ribosomal_S17_arc-typ Family
IPR019984 Ribosomal protein S17, bacterial-type Ribosomal_S17_bac-type Family

1 Contains

DB identifier Name Short Name Type
IPR019979 Ribosomal protein S17, conserved site Ribosomal_S17_CS Conserved_site

5 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10744 PANTHER IPR000266
PF00366 PFAM IPR000266
PR00973 PRINTS IPR000266
PD001295 PRODOM IPR000266
MF_01345_B HAMAP IPR000266

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein S17   GO:0003735 structural constituent of ribosome
Ribosomal protein S17   GO:0006412 translation
Ribosomal protein S17   GO:0005622 intracellular
Ribosomal protein S17   GO:0005840 ribosome

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein S17   GO:0003735 structural constituent of ribosome
Ribosomal protein S17   GO:0006412 translation
Ribosomal protein S17   GO:0005622 intracellular
Ribosomal protein S17   GO:0005840 ribosome

0 Parent Features

17 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087114 A1Z8U9 Drosophila melanogaster
FBpp0087115 Q0E9B6 Drosophila melanogaster
FBpp0072184 Q9W199 Drosophila melanogaster
FBpp0276576 Q28ZX8 Drosophila pseudoobscura
FBpp0168166 B4KTL7 Drosophila mojavensis
FBpp0168477 B4KNV9 Drosophila mojavensis
FBpp0235972 B4LJS1 Drosophila virilis
FBpp0236552 B4LJU8 Drosophila virilis
FBpp0256485 B4PAV9 Drosophila yakuba
FBpp0258474 B4P5M1 Drosophila yakuba
A8X0V2_CAEBR A8X0V2 Caenorhabditis briggsae
H2W6K9_CAEJA H2W6K9 Caenorhabditis japonica
G0NU72_CAEBE G0NU72 Caenorhabditis brenneri
Q20206_CAEEL Q20206 Caenorhabditis elegans
RS11_DROYA Q6XHX5 Drosophila yakuba
E3M7Y9_CAERE E3M7Y9 Caenorhabditis remanei
RS11_DROPS Q292D0 Drosophila pseudoobscura