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Protein Domain : IPR017184

Name  Serine/threonine-protein kinase Unc-51 Short Name  Ser/Thr_kinase_Unc51
Type  Family Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry represents serine/threonine-protein kinases () such as Unc-51 from Caenorhabditis elegans. Unc-51 is important for axonal elongation and axonal guidance []. It is required for either the maintenance of axons (membrane turnover) or for an unknown neuronal function. C elegans worms lacking Unc-51 exhibit various abnormalities in axonal elongation and axonal structures. Unc-51 could also help control cell size along with Bec-1, as mutations in their corresponding genes results in a reduction in small body size without affecting cell number [].

Publication Counts Displayer

0 Child Features

5 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom Domain
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF037369 PIRSF IPR017184

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

10 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075677 Q9VU14 Drosophila melanogaster
FBpp0289788 Q8MQJ7 Drosophila melanogaster
FBpp0275495 Q2LYW8 Drosophila pseudoobscura
FBpp0162868 B4L0U4 Drosophila mojavensis
FBpp0228401 B4LBJ6 Drosophila virilis
FBpp0265106 B4PGV0 Drosophila yakuba
A8WL55_CAEBR A8WL55 Caenorhabditis briggsae
Q8I171_DROVI Q8I171 Drosophila virilis
UNC51_CAEEL Q23023 Caenorhabditis elegans
E3MES4_CAERE E3MES4 Caenorhabditis remanei