modENCODE |  Help |  blog

Protein Domain : IPR015496

Name  Ubiquilin Short Name  Ubiquilin
Type  Family Description  Ubiquitin []is a protein of seventy six amino acid residues, found in all eukaryotic cells and whose sequence is extremely well conserved from protozoan to vertebrates. It is widely known as a post-translational tag used to signal a protein's hydrolytic destruction. Other functions for ubiquitin, depend on its differential internal isopeptide linkages. In addition, several ubiquitin-like proteins have been discovered from genome-sequencing efforts, other structural studies, and genetic screens. These new data show that proteins with the ubiquitin domain are adaptable, transposable genetic elements, which have been appended to other genes and utilised for many different cellular functions, depending on the ubiquitin-like protein's identity, subcellular location, and method of covalent attachment. The post-translational ligation of proteins to members of the ubiquitin superfamily can signal many different fates for the target protein [].Ubiquitin is a globular protein, the last four C-terminal residues (Leu-Arg-Gly-Gly) extending from the compact structure to form a 'tail' important for its function. The latter is mediated by the covalent conjugation of ubiquitin to target proteins, by an isopeptide linkage between the C-terminal glycine and the epsilon amino group of lysine residues in the target proteins.Ubiquilin is a Ubiquitin-like (UBL) protein and has an N-terminal UBL domain and a C-terminal Ub-associated (UBA) domain in its structure.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR028799 Ubiquilin-1 UBQLN1 Family
IPR028430 Ubiquilin-2 Ubiquilin-2 Family

4 Contains

DB identifier Name Short Name Type
IPR000626 Ubiquitin-like Ubiquitin-like Domain
IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal UBA/Ts_N Domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote UBA/transl_elong_EF1B_N_euk Domain
IPR006636 Heat shock chaperonin-binding STI1_HS-bd Domain

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

26 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0078563 Q8IPM2 Drosophila melanogaster
FBpp0074519 Q9VWD9 Drosophila melanogaster
FBpp0071182 Q7KVT0 Drosophila melanogaster
FBpp0071186 Q8IRN3 Drosophila melanogaster
FBpp0281352 Q295G2 Drosophila pseudoobscura
FBpp0285692 Q29HY5 Drosophila pseudoobscura
FBpp0160325 B4L7Z6 Drosophila mojavensis
FBpp0173562 B4KAB1 Drosophila mojavensis
FBpp0224847 B4M696 Drosophila virilis
FBpp0230378 B4MAQ9 Drosophila virilis
FBpp0260876 B4PZD9 Drosophila yakuba
FBpp0262463 B4Q0B6 Drosophila yakuba
FBpp0270428 B4PTS6 Drosophila yakuba
A8XBS9_CAEBR A8XBS9 Caenorhabditis briggsae
H2WB58_CAEJA H2WB58 Caenorhabditis japonica
K7HAQ0_CAEJA K7HAQ0 Caenorhabditis japonica
K7HAP9_CAEJA K7HAP9 Caenorhabditis japonica
G0P304_CAEBE G0P304 Caenorhabditis brenneri
G0P3K4_CAEBE G0P3K4 Caenorhabditis brenneri
G5EG66_CAEEL G5EG66 Caenorhabditis elegans
G5EC78_CAEEL G5EC78 Caenorhabditis elegans
G5EFF7_CAEEL G5EFF7 Caenorhabditis elegans
Q8T0K3_DROME Q8T0K3 Drosophila melanogaster
A8E6G3_DROME A8E6G3 Drosophila melanogaster
Q6NMU6_DROME Q6NMU6 Drosophila melanogaster
E3NBU4_CAERE E3NBU4 Caenorhabditis remanei