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Protein Domain : IPR014742

Name  Adaptor protein Cbl, SH2-like Short Name  Adaptor_Cbl_SH2-like
Type  Domain Description  Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface.The N-terminal region of Cbl contains a Cbl-type phosphotyrosine-binding (Cbl-PTB) domain, which is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle (4H) domain, an EF hand-like calcium-binding domain, and a divergent SH2-like domain. The calcium-bound EF-hand wedges between the 4H and SH2 domains, and roughly determines their relative orientation. The Cbl-PTB domain has also been named Cbl N-terminal (Cbl-N) or tyrosine kinase binding (TKB) domain [, ].The N-terminal 4H domain contains four long alpha-helices. The C and D helices in this domain pack against the adjacent EF-hand-like domain, and a highly conserved loop connecting the A and B helices contacts the SH2-like domain. The EF-hand motif is similar to classical EF-hand proteins. The SH2-likedomain retains the general helix-sheet-helix architecture of the SH2 fold, but lacks the secondary beta-sheet, comprising beta-strands D', E and F, and also a prominent BG loop [].This entry represents the SH2-like domain.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PF02762 PFAM IPR014742

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR000980 SH2 domain SH2 Domain

14 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076341 O46034 Drosophila melanogaster
FBpp0076342 Q9VSK2 Drosophila melanogaster
FBpp0275585 Q2LYL3 Drosophila pseudoobscura
FBpp0162050 B4KYE3 Drosophila mojavensis
FBpp0227392 B4LDS5 Drosophila virilis
FBpp0265752 B4PG25 Drosophila yakuba
A8X5V5_CAEBR A8X5V5 Caenorhabditis briggsae
H2W705_CAEJA H2W705 Caenorhabditis japonica
G0N7K2_CAEBE G0N7K2 Caenorhabditis brenneri
Q19019_CAEEL Q19019 Caenorhabditis elegans
Q95ZR5_CAEEL Q95ZR5 Caenorhabditis elegans
Q6ABG8_CAEEL Q6ABG8 Caenorhabditis elegans
P91683_DROME P91683 Drosophila melanogaster
E3MA78_CAERE E3MA78 Caenorhabditis remanei