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Protein Domain : IPR008343

Name  Mitogen-activated protein (MAP) kinase phosphatase Short Name  MKP
Type  Family Description  MAP Kinase Phosphatases (MKPs) are members of the dual specificity phosphatase family [, ]. MKPs constitute a class of phosphatases that reverse the activation of MAP (mitogen activated protein) kinases by dephosphorylating critical tyrosineand threonine residues []. This regulation is mediated via interaction of aKinase Interaction Motif (KIM) with the common docking domain of the kinase- this motif is shared with a number of other protein families that interactwith MAP kinases: these include kinases (MEKs), phosphatases (PTP-SL) andtranscription factors (Elk1). MKPs also share an active site motif with theprotein tyrosine phosphatases (PTPs). Different MKPs exhibit specificitytowards different members of the MAP kinase family [].The structureof the MPK catalytic domain is similar to that of the PTPs- the fold exhibits a complex mixed alpha-/beta-architecture. Thecatalytic mechanism involves a general acid (Asp92 in 1VHR) and a catalyticcysteine (130 in 1VHR), which acts as a nucleophile.

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR001763 Rhodanese-like domain Rhodanese-like_dom Domain
IPR000340 Dual specificity phosphatase, catalytic domain Dual-sp_phosphatase_cat-dom Domain
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain Dual-sp_phosphatase_subgr_cat Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF000939 PIRSF IPR008343
PR01764 PRINTS IPR008343

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Mitogen-activated protein (MAP) kinase phosphatase   GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Mitogen-activated protein (MAP) kinase phosphatase   GO:0006470 protein dephosphorylation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Mitogen-activated protein (MAP) kinase phosphatase   GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Mitogen-activated protein (MAP) kinase phosphatase   GO:0006470 protein dephosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR024950 Dual specificity phosphatase DUSP Family

21 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074802 Q9VVW5 Drosophila melanogaster
FBpp0303122 M9PG13 Drosophila melanogaster
FBpp0286123 Q29DI8 Drosophila pseudoobscura
FBpp0161026 B4KZ97 Drosophila mojavensis
FBpp0227929 B4LD28 Drosophila virilis
FBpp0267535 B4PH00 Drosophila yakuba
FBpp0267794 B4IU90 Drosophila yakuba
A8WUH4_CAEBR A8WUH4 Caenorhabditis briggsae
H2VZW4_CAEJA H2VZW4 Caenorhabditis japonica
H2VNN4_CAEJA H2VNN4 Caenorhabditis japonica
G0PNP1_CAEBE G0PNP1 Caenorhabditis brenneri
G0NAX8_CAEBE G0NAX8 Caenorhabditis brenneri
VHP1_CAEEL Q10038 Caenorhabditis elegans
VHP1_CAEEL-3 Q10038-3 Caenorhabditis elegans
VHP1_CAEEL-2 Q10038-2 Caenorhabditis elegans
V6CIV8_CAEEL V6CIV8 Caenorhabditis elegans
O44128_CAEEL O44128 Caenorhabditis elegans
DUSK3_DROME-2 Q9VVW5-2 Drosophila melanogaster
E3N3W2_CAERE E3N3W2 Caenorhabditis remanei
E3M4I9_CAERE E3M4I9 Caenorhabditis remanei
E3NQ78_CAERE E3NQ78 Caenorhabditis remanei