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Protein Domain : IPR008343

Name	Mitogen-activated protein (MAP) kinase phosphatase	Short Name	MKP
Type	Family	Description	MAP Kinase Phosphatases (MKPs) are members of the dual specificity phosphatase family [, ]. MKPs constitute a class of phosphatases that reverse the activation of MAP (mitogen activated protein) kinases by dephosphorylating critical tyrosineand threonine residues []. This regulation is mediated via interaction of aKinase Interaction Motif (KIM) with the common docking domain of the kinase- this motif is shared with a number of other protein families that interactwith MAP kinases: these include kinases (MEKs), phosphatases (PTP-SL) andtranscription factors (Elk1). MKPs also share an active site motif with theprotein tyrosine phosphatases (PTPs). Different MKPs exhibit specificitytowards different members of the MAP kinase family [].The structureof the MPK catalytic domain is similar to that of the PTPs- the fold exhibits a complex mixed alpha-/beta-architecture. Thecatalytic mechanism involves a general acid (Asp92 in 1VHR) and a catalyticcysteine (130 in 1VHR), which acts as a nucleophile.

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier	Name	Short Name	Type
IPR001763	Rhodanese-like domain	Rhodanese-like_dom	Domain
IPR000340	Dual specificity phosphatase, catalytic domain	Dual-sp_phosphatase_cat-dom	Domain
IPR020422	Dual specificity phosphatase, subgroup, catalytic domain	Dual-sp_phosphatase_subgr_cat	Domain

2 Cross References

Identifier	Source . Name	Subject . Primary Identifier
PIRSF000939	PIRSF	IPR008343
PR01764	PRINTS	IPR008343

3 Data Sets

Name	URL
TrEMBL data set	http://www.ebi.ac.uk/trembl/
InterPro data set
InterPro GO Annotation data set

0 Found In

2 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Mitogen-activated protein (MAP) kinase phosphatase		GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
	Mitogen-activated protein (MAP) kinase phosphatase		GO:0006470	protein dephosphorylation

2 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Mitogen-activated protein (MAP) kinase phosphatase		GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
	Mitogen-activated protein (MAP) kinase phosphatase		GO:0006470	protein dephosphorylation

1 Parent Features

DB identifier	Name	Short Name	Type
IPR024950	Dual specificity phosphatase	DUSP	Family

21 Proteins

DB identifier	Primary Accession	Organism . Name
FBpp0074802	Q9VVW5	Drosophila melanogaster
FBpp0303122	M9PG13	Drosophila melanogaster
FBpp0286123	Q29DI8	Drosophila pseudoobscura
FBpp0161026	B4KZ97	Drosophila mojavensis
FBpp0227929	B4LD28	Drosophila virilis
FBpp0267535	B4PH00	Drosophila yakuba
FBpp0267794	B4IU90	Drosophila yakuba
A8WUH4_CAEBR	A8WUH4	Caenorhabditis briggsae
H2VZW4_CAEJA	H2VZW4	Caenorhabditis japonica
H2VNN4_CAEJA	H2VNN4	Caenorhabditis japonica
G0PNP1_CAEBE	G0PNP1	Caenorhabditis brenneri
G0NAX8_CAEBE	G0NAX8	Caenorhabditis brenneri
VHP1_CAEEL	Q10038	Caenorhabditis elegans
VHP1_CAEEL-3	Q10038-3	Caenorhabditis elegans
VHP1_CAEEL-2	Q10038-2	Caenorhabditis elegans
V6CIV8_CAEEL	V6CIV8	Caenorhabditis elegans
O44128_CAEEL	O44128	Caenorhabditis elegans
DUSK3_DROME-2	Q9VVW5-2	Drosophila melanogaster
E3N3W2_CAERE	E3N3W2	Caenorhabditis remanei
E3M4I9_CAERE	E3M4I9	Caenorhabditis remanei
E3NQ78_CAERE	E3NQ78	Caenorhabditis remanei

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