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Protein Domain : IPR019821

Name  Kinesin, motor region, conserved site Short Name  Kinesin_motor_CS
Type  Conserved_site Description  Kinesin [, , ]is a microtubule-associated force-producing protein that may play a role in organelle transport. The kinesin motor activity is directed toward the microtubule's plus end. Kinesin is an oligomeric complex composed of two heavy chains and two light chains. The maintenance of the quaternary structure does not require interchain disulphide bonds.The heavy chain is composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it is known to hydrolyse ATP, to bind and move on microtubules), a central alpha-helical coiled coil domain that mediates the heavy chain dimerisation; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.A number of proteins have been recently found that contain a domain similar to that of the kinesin 'motor' domain [, ]:Drosophila melanogasterclaret segregational protein (ncd). Ncd is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The ncd motor activity is directed toward the microtubule's minus end.Homo sapiensCENP-E []. CENP-E is a protein that associates with kinetochores during chromosome congression, relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division. CENP-E is probably an important motor molecule in chromosome movement and/or spindle elongation.H. sapiens mitotic kinesin-like protein-1 (MKLP-1), a motor protein whose activity is directed toward the microtubule's plus end.Saccharomyces cerevisiaeKAR3 protein, which is essential for nuclear fusion during mating. KAR3 may mediate microtubule sliding during nuclear fusion and possibly mitosis.S. cerevisiae CIN8 and KIP1 proteins which are required for the assembly of the mitotic spindle. Both proteins seem to interact with spindle microtubules to produce an outwardly directed force acting upon the poles.Emericella nidulans(Aspergillus nidulans) bimC, which plays an important role in nuclear division.A. nidulans klpA.Caenorhabditis elegansunc-104, which may be required for the transport of substances needed for neuronal cell differentiation.C. elegans osm-3.Xenopus laevisEg5, which may be involved in mitosis.Arabidopsis thalianaKatA, KatB and katC.Chlamydomonas reinhardtiiFLA10/KHP1 and KLP1. Both proteins seem to play a role in the rotation or twisting of the microtubules of the flagella.C. elegans hypothetical protein T09A5.2.The kinesin motor domain is located in the N-terminal part of most of the above proteins, with the exception of KAR3, klpA, and ncd where it is located in the C-terminal section.The kinesin motor domain contains about 330 amino acids. An ATP-binding motif of type A is found near position 80 to 90, the C-terminal half of the domain is involved in microtubule-binding.The signature pattern for this entry is derived from a conserved decapeptide inside the microtubule-binding region.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00411 PROSITE IPR019821

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR001752 Kinesin, motor domain Kinesin_motor_dom Domain

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Kinesin, motor region, conserved site   GO:0003777 microtubule motor activity
Kinesin, motor region, conserved site   GO:0005524 ATP binding
Kinesin, motor region, conserved site   GO:0007018 microtubule-based movement

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Kinesin, motor region, conserved site   GO:0003777 microtubule motor activity
Kinesin, motor region, conserved site   GO:0005524 ATP binding
Kinesin, motor region, conserved site   GO:0007018 microtubule-based movement

0 Parent Features

224 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086328 P17210 Drosophila melanogaster
FBpp0073363 P18105 Drosophila melanogaster
FBpp0088260 Q9V4A1 Drosophila melanogaster
FBpp0079795 Q9VKH9 Drosophila melanogaster
FBpp0072616 P46863 Drosophila melanogaster
FBpp0073331 Q960Z0 Drosophila melanogaster
FBpp0084900 P20480 Drosophila melanogaster
FBpp0076861 Q9VRK9 Drosophila melanogaster
FBpp0084581 Q9VB25 Drosophila melanogaster
FBpp0080864 Q9VIP4 Drosophila melanogaster
FBpp0071885 Q9W1U4 Drosophila melanogaster
FBpp0073083 Q9VZF5 Drosophila melanogaster
FBpp0086490 A1ZA18 Drosophila melanogaster
FBpp0075762 P46867 Drosophila melanogaster
FBpp0086041 Q9V877 Drosophila melanogaster
FBpp0070432 Q9XZ29 Drosophila melanogaster
FBpp0079608 Q9VKW4 Drosophila melanogaster
FBpp0112000 A1ZAJ2 Drosophila melanogaster
FBpp0297759 D2NUG1 Drosophila melanogaster
FBpp0304032 E1JHE1 Drosophila melanogaster
FBpp0304513 M9PCX3 Drosophila melanogaster
FBpp0304512 M9PD87 Drosophila melanogaster
FBpp0304514 M9PFL9 Drosophila melanogaster
FBpp0304511 Q9VKI0 Drosophila melanogaster
FBpp0281870 Q297T2 Drosophila pseudoobscura
FBpp0275286 Q2LZL5 Drosophila pseudoobscura
FBpp0277543 Q291R3 Drosophila pseudoobscura
FBpp0273243 Q29GT7 Drosophila pseudoobscura
FBpp0272202 Q29G01 Drosophila pseudoobscura
FBpp0276257 Q28YN3 Drosophila pseudoobscura