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Protein Domain : IPR005331

Name  Sulfotransferase Short Name  Sulfotransferase
Type  Family Description  This entry consists of a number of carbohydrate sulphotransferases that transfer sulphate to carbohydrate groups in glycoproteins and glycolipids. These include: Carbohydrate sulphotransferases 8 and 9, which transfer sulphate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans []. They function in the biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulphation of their carbohydrate structures.Carbohydrate sulphotransferase 10, which transfers sulphate to position 3 of the terminal glucuronic acid in both protein- and lipid-linked oligosaccharides []. It directs the biosynthesis of the HNK-1 carbohydrate structure, a sulphated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. Carbohydrate sulphotransferases 11 - 13, which catalyze the transfer of sulphate to position 4 of the GalNAc residue of chondroitin []. Chondroitin sulphate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Some, thought not all, of these enzymes also transfer sulphate to dermatan.Carbohydrate sulphotransferase D4ST1, which transfers sulphate to position 4 of the GalNAc residue of dermatan sulphate [].Heparan sulphate 2-O-sulphotransferase (HS2ST). Heparan sulphate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development [].Heparan-sulphate 6-O-sulphotransferase (HS6ST), which catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate [].Chondroitin 6-sulphotransferase catalyses the transfer of sulphate to position 6 of the N-acetylgalactosamine residue of chondroitin [].

Publication Counts Displayer

4 Child Features

DB identifier Name Short Name Type
IPR007734 Heparan sulphate 2-O-sulfotransferase Heparan_SO4_2-O-STrfase Family
IPR007669 Protein of unknown function DUF595 DUF595 Family
IPR010635 Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase Heparan_SO4-6-sulfoTrfase Family
IPR018011 Carbohydrate sulfotransferase-related Carb_sulfotransferase-rel Family

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF03567 PFAM IPR005331

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Sulfotransferase   GO:0008146 sulfotransferase activity
Sulfotransferase   GO:0016021 integral component of membrane

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Sulfotransferase   GO:0008146 sulfotransferase activity
Sulfotransferase   GO:0016021 integral component of membrane

0 Parent Features

169 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0080500 Q9VJG5 Drosophila melanogaster
FBpp0078716 Q9VMS3 Drosophila melanogaster
FBpp0080826 P25722 Drosophila melanogaster
FBpp0074780 Q86BJ3 Drosophila melanogaster
FBpp0083255 Q9VDR6 Drosophila melanogaster
FBpp0289941 Q8IRG5 Drosophila melanogaster
FBpp0289938 Q9W070 Drosophila melanogaster
FBpp0304915 M9PBI7 Drosophila melanogaster
FBpp0286100 B5DRU8 Drosophila pseudoobscura
FBpp0279851 Q29M12 Drosophila pseudoobscura
FBpp0274439 Q2M058 Drosophila pseudoobscura
FBpp0286106 B5DRU2 Drosophila pseudoobscura
FBpp0278468 Q29L92 Drosophila pseudoobscura
FBpp0286101 B5DRU7 Drosophila pseudoobscura
FBpp0286102 B5DRU6 Drosophila pseudoobscura
FBpp0286103 B5DRU5 Drosophila pseudoobscura
FBpp0286104 B5DRU4 Drosophila pseudoobscura
FBpp0286105 B5DRU3 Drosophila pseudoobscura
FBpp0288001 Q29K51 Drosophila pseudoobscura
FBpp0161224 B4KWW3 Drosophila mojavensis
FBpp0159536 B4KE38 Drosophila mojavensis
FBpp0159792 B4KI39 Drosophila mojavensis
FBpp0162753 B4KZM1 Drosophila mojavensis
FBpp0162754 B4KZM2 Drosophila mojavensis
FBpp0162755 B4KZM3 Drosophila mojavensis
FBpp0162757 B4KZM5 Drosophila mojavensis
FBpp0162758 B4KZM6 Drosophila mojavensis
FBpp0162759 B4KZM7 Drosophila mojavensis
FBpp0162761 B4KZM8 Drosophila mojavensis
FBpp0166436 B4KK65 Drosophila mojavensis