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Protein Domain : IPR015224

Name  Talin, central Short Name  Talin_cent
Type  Domain Description  This domain adopts a structure consisting of five alpha helices that fold into a bundle. It contains a Vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of the VBS causes subsequent recruitment of Vinculin, which enables maturation of small integrin/talin complexes into more stable adhesions. Formation of the complex between VBS and Vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin [].

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF09141 PFAM IPR015224
G3DSA:1.20.1420.10 GENE3D IPR015224
SSF109880 SSF IPR015224

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR015710 Talin-1 Talin-1 Family

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Talin, central   GO:0005200 structural constituent of cytoskeleton
Talin, central   GO:0007016 cytoskeletal anchoring at plasma membrane
Talin, central   GO:0001726 ruffle
Talin, central   GO:0005925 focal adhesion

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Talin, central   GO:0005200 structural constituent of cytoskeleton
Talin, central   GO:0007016 cytoskeletal anchoring at plasma membrane
Talin, central   GO:0001726 ruffle
Talin, central   GO:0005925 focal adhesion

0 Parent Features

14 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0293740 Q9VSL8 Drosophila melanogaster
FBpp0293741 M9NDM3 Drosophila melanogaster
FBpp0305319 M9PBW9 Drosophila melanogaster
FBpp0305320 M9PEJ8 Drosophila melanogaster
FBpp0277245 Q29FI8 Drosophila pseudoobscura
FBpp0162125 B4KZ53 Drosophila mojavensis
FBpp0227466 B4LEJ9 Drosophila virilis
FBpp0265762 B4PG07 Drosophila yakuba
A8Y1N6_CAEBR A8Y1N6 Caenorhabditis briggsae
K7HYS4_CAEJA K7HYS4 Caenorhabditis japonica
G0MNX4_CAEBE G0MNX4 Caenorhabditis brenneri
G5EGK1_CAEEL G5EGK1 Caenorhabditis elegans
Q95XN3_CAEEL Q95XN3 Caenorhabditis elegans
E3LXS8_CAERE E3LXS8 Caenorhabditis remanei