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Protein Domain : IPR001251

Name  CRAL-TRIO domain Short Name  CRAL-TRIO_dom
Type  Domain Description  The CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules []. The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor.The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and mammalian retinaldehyde- and alpha-tocopherol-binding proteins. The domain may either constitute all of the protein or only part of it [, , , ].The structure of the domain in SEC14 proteins has been determined []. The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and 5 form a parallel beta sheet with strands 1 and 6 being anti-parallel. The structure also identified a hydrophobic binding pocket for lipid binding.

Publication Counts Displayer

0 Child Features

0 Contains

6 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00650 PFAM IPR001251
PF13716 PFAM IPR001251
PS50191 PROFILE IPR001251
SM00516 SMART IPR001251
G3DSA:3.40.525.10 GENE3D IPR001251
SSF52087 SSF IPR001251

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

1 Found In

DB identifier Name Short Name Type
IPR001071 Cellular retinaldehyde binding/alpha-tocopherol transport CRAL-bd_toc_tran Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

315 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0080778 Q8T9G7 Drosophila melanogaster
FBpp0080777 Q9VIW1 Drosophila melanogaster
FBpp0099554 Q9W323 Drosophila melanogaster
FBpp0099555 Q9W324 Drosophila melanogaster
FBpp0099556 Q8IRM7 Drosophila melanogaster
FBpp0099559 Q59E68 Drosophila melanogaster
FBpp0072855 Q8I941 Drosophila melanogaster
FBpp0099382 Q2MGL8 Drosophila melanogaster
FBpp0073145 Q6NLM7 Drosophila melanogaster
FBpp0070865 Q9W408 Drosophila melanogaster
FBpp0099381 Q2MGL9 Drosophila melanogaster
FBpp0090954 Q8I935 Drosophila melanogaster
FBpp0100151 Q59DT9 Drosophila melanogaster
FBpp0075707 Q9VTY1 Drosophila melanogaster
FBpp0087615 Q7K1M4 Drosophila melanogaster
FBpp0088011 A1Z742 Drosophila melanogaster
FBpp0088010 A1Z741 Drosophila melanogaster
FBpp0088009 Q7JUR6 Drosophila melanogaster
FBpp0087617 Q8SXR4 Drosophila melanogaster
FBpp0087586 A1Z7X8 Drosophila melanogaster
FBpp0084327 Q8IMS2 Drosophila melanogaster
FBpp0084326 Q9VBJ2 Drosophila melanogaster
FBpp0297349 D1Z396 Drosophila melanogaster
FBpp0078953 Q8IPJ5 Drosophila melanogaster
FBpp0080749 Q9VIW5 Drosophila melanogaster
FBpp0080750 Q8INW5 Drosophila melanogaster
FBpp0080748 Q9I7M3 Drosophila melanogaster
FBpp0079076 Q9VM11 Drosophila melanogaster
FBpp0083837 Q9VCJ2 Drosophila melanogaster
FBpp0072461 Q8SYC4 Drosophila melanogaster