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Protein Domain : IPR000156

Name  Ran binding domain Short Name  Ran_bind_dom
Type  Domain Description  Ran is an evolutionary conserved member of the Ras superfamily that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran Binding Protein 1 (RanBP1) has guanine nucleotide dissociation inhibitory activity, specific for the GTP form of Ran and also functions to stimulate Ran GTPase activating protein(GAP)-mediated GTP hydrolysis by Ran. RanBP1 contributes to maintaining the gradient of RanGTP across the nuclear envelope high (GDI activity) or the cytoplasmic levels of RanGTP low (GAP cofactor) [].All RanBP1 proteins contain an approx 150 amino acid residue Ran binding domain. Ran BP1 binds directly to RanGTP with high affinity.There are four sites of contact between Ran and the Ran binding domain. One of these involves binding of the C-terminal segment of Ran to a groove on the Ran binding domain that is analogous to the surface utilised in the EVH1-peptide interaction []. Nup358 contains four Ran binding domains. The structure of the first of these is known [].

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00638 PFAM IPR000156
PS50196 PROFILE IPR000156
SM00160 SMART IPR000156

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ran binding domain   GO:0046907 intracellular transport

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ran binding domain   GO:0046907 intracellular transport

1 Parent Features

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain

48 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0084188 Q9VBU7 Drosophila melanogaster
FBpp0113115 Q8T4F7 Drosophila melanogaster
FBpp0289946 Q4V4X9 Drosophila melanogaster
FBpp0289945 Q9VTQ2 Drosophila melanogaster
FBpp0083859 Q9VCI7 Drosophila melanogaster
FBpp0087861 Q7K0D8 Drosophila melanogaster
FBpp0274862 B5DLX3 Drosophila pseudoobscura
FBpp0276573 Q28ZW9 Drosophila pseudoobscura
FBpp0301879 I5APW4 Drosophila pseudoobscura
FBpp0281032 B5DXH1 Drosophila pseudoobscura
FBpp0282123 Q299D1 Drosophila pseudoobscura
FBpp0168131 B4KU69 Drosophila mojavensis
FBpp0168474 B4KNX0 Drosophila mojavensis
FBpp0171618 B4K5A7 Drosophila mojavensis
FBpp0172856 B4KDP6 Drosophila mojavensis
FBpp0234186 B4MCP0 Drosophila virilis
FBpp0236549 B4LJM3 Drosophila virilis
FBpp0239067 B4M0G0 Drosophila virilis
FBpp0239132 B4M5G2 Drosophila virilis
FBpp0257031 B4PBP8 Drosophila yakuba
FBpp0264188 B4P293 Drosophila yakuba
FBpp0268589 B4PUA3 Drosophila yakuba
FBpp0268939 B4PNX1 Drosophila yakuba
A8XHJ8_CAEBR A8XHJ8 Caenorhabditis briggsae
A8XHK3_CAEBR A8XHK3 Caenorhabditis briggsae
A8X9U5_CAEBR A8X9U5 Caenorhabditis briggsae
A8WU10_CAEBR A8WU10 Caenorhabditis briggsae
K7HJQ1_CAEJA K7HJQ1 Caenorhabditis japonica
H2VLN4_CAEJA H2VLN4 Caenorhabditis japonica
H2W9N3_CAEJA H2W9N3 Caenorhabditis japonica