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Protein Domain : IPR000215

Name  Serpin family Short Name  Serpin_fam
Type  Family Description  Protein protease inhibitors constitute a very important mechanism for regulating proteolytic activity. Serpins (SERine Proteinase INhibitors) belong to MEROPS inhibitor family I4, clan ID. Most serpin family members are indeed serine protease inhibitors, but several have additional cross-class inhibition functions and inhibit cysteine protease family members such as the caspases and cathepsins [, ]. Others, such as ovalbumin, are incapable of protease inhibition and serve other functions []. The serpins are a functionally diverse family of proteins with a highly conserved structure. Members of the serpin family have been identified in a variety of organisms including animals, viruses, plants [, ], archaea and bacteria [, ]. Vertebrate serpins are involved in fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression []. A fungal serpin (celpin) has also been characterised and it is thought to protect the cellulose-degrading apparatus (cellulosome) against proteolytic degradation [].Serpins share a highly conserved core structure that is critical for their functioning as serine protease inhibitors []. Inhibitory serpins comprise several alpha-helix and beta-strands together with an external reactive centre loop (RCL) containing the active site recognised by the target enzyme. Serpins form covalent complexes with target proteases. Their mechanism of protease inhibition is known as irreversible "trapping" , in which a rapid conformational change traps the cognate protease in a covalent complex.

Publication Counts Displayer

6 Child Features

DB identifier Name Short Name Type
IPR015553 Plasma protease C1 inhibitor C1-inh Family
IPR015555 Antithrombin-III AT-III Family
IPR015556 Plasminogen activator inhibitor-2 PAI-2 Family
IPR015557 Leukocyte elastase inhibitor (serpin B1) Serpin_B1 Family
IPR000227 Angiotensinogen Angiotensinogen Family
IPR000240 Serpin B9/maspin Serpin_B9/Maspin Family

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR11461 PANTHER IPR000215

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serpin family   GO:0005615 extracellular space

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serpin family   GO:0005615 extracellular space

0 Parent Features

225 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087306 Q7K508 Drosophila melanogaster
FBpp0088112 Q7KA66 Drosophila melanogaster
FBpp0079171 Q9VLU4 Drosophila melanogaster
FBpp0088124 Q8SYY7 Drosophila melanogaster
FBpp0099762 A1Z6V5 Drosophila melanogaster
FBpp0079094 Q9VLZ8 Drosophila melanogaster
FBpp0079243 Q9VLQ7 Drosophila melanogaster
FBpp0289586 Q7YTY6 Drosophila melanogaster
FBpp0082596 Q9VFC2 Drosophila melanogaster
FBpp0088123 Q7JWX3 Drosophila melanogaster
FBpp0085523 Q7K8Y5 Drosophila melanogaster
FBpp0089192 Q8MPN6 Drosophila melanogaster
FBpp0089193 Q8MM39 Drosophila melanogaster
FBpp0089189 Q8MPN8 Drosophila melanogaster
FBpp0089207 Q8MPN7 Drosophila melanogaster
FBpp0085524 Q7K8Y3 Drosophila melanogaster
FBpp0089191 Q8MM49 Drosophila melanogaster
FBpp0089208 Q8MPN5 Drosophila melanogaster
FBpp0078950 Q9V3N1 Drosophila melanogaster
FBpp0080979 Q9VII7 Drosophila melanogaster
FBpp0110074 Q4V3G2 Drosophila melanogaster
FBpp0110138 Q0E8V6 Drosophila melanogaster
FBpp0110068 Q3HKQ3 Drosophila melanogaster
FBpp0085497 Q8SZF4 Drosophila melanogaster
FBpp0289587 A1Z6R3 Drosophila melanogaster
FBpp0085912 Q7JV69 Drosophila melanogaster
FBpp0079179 Q9VLV3 Drosophila melanogaster
FBpp0300938 M9NEE3 Drosophila melanogaster
FBpp0074612 Q9VWB4 Drosophila melanogaster
FBpp0085495 A1Z6R4 Drosophila melanogaster