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Protein Domain : IPR023796

Name  Serpin domain Short Name  Serpin_dom
Type  Domain Description  Serpins (SERine Proteinase INhibitors) belong to MEROPS inhibitor family I4, clan ID. Most serpin family members are indeed serine protease inhibitors, but several have additional cross-class inhibition functions and inhibit cysteine protease family members such as the caspases and cathepsins [, ]. Others, such as ovalbumin, are incapable of protease inhibition and serve other functions []. Serpins share a highly conserved core structure that is critical for their functioning as serine protease inhibitors []. Inhibitory serpins comprise several alpha-helix and beta-strands together with an external reactive centre loop (RCL) containing the active site recognised by the target enzyme. Serpins form covalent complexes with target proteases. Their mechanism of protease inhibition is known as irreversible "trapping" , in which a rapid conformational change traps the cognate protease in a covalent complex.This entry represents the structural domain of serpins.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00079 PFAM IPR023796
SM00093 SMART IPR023796
SSF56574 SSF IPR023796

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

264 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087306 Q7K508 Drosophila melanogaster
FBpp0088112 Q7KA66 Drosophila melanogaster
FBpp0079171 Q9VLU4 Drosophila melanogaster
FBpp0088124 Q8SYY7 Drosophila melanogaster
FBpp0099762 A1Z6V5 Drosophila melanogaster
FBpp0079094 Q9VLZ8 Drosophila melanogaster
FBpp0079243 Q9VLQ7 Drosophila melanogaster
FBpp0289586 Q7YTY6 Drosophila melanogaster
FBpp0082596 Q9VFC2 Drosophila melanogaster
FBpp0088123 Q7JWX3 Drosophila melanogaster
FBpp0085523 Q7K8Y5 Drosophila melanogaster
FBpp0089192 Q8MPN6 Drosophila melanogaster
FBpp0089193 Q8MM39 Drosophila melanogaster
FBpp0089189 Q8MPN8 Drosophila melanogaster
FBpp0089207 Q8MPN7 Drosophila melanogaster
FBpp0085524 Q7K8Y3 Drosophila melanogaster
FBpp0089191 Q8MM49 Drosophila melanogaster
FBpp0089208 Q8MPN5 Drosophila melanogaster
FBpp0078950 Q9V3N1 Drosophila melanogaster
FBpp0080979 Q9VII7 Drosophila melanogaster
FBpp0110074 Q4V3G2 Drosophila melanogaster
FBpp0110138 Q0E8V6 Drosophila melanogaster
FBpp0110068 Q3HKQ3 Drosophila melanogaster
FBpp0085497 Q8SZF4 Drosophila melanogaster
FBpp0289587 A1Z6R3 Drosophila melanogaster
FBpp0085912 Q7JV69 Drosophila melanogaster
FBpp0079179 Q9VLV3 Drosophila melanogaster
FBpp0300938 M9NEE3 Drosophila melanogaster
FBpp0074612 Q9VWB4 Drosophila melanogaster
FBpp0085495 A1Z6R4 Drosophila melanogaster