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Protein Domain : IPR023795

Name  Serpin, conserved site Short Name  Serpin_CS
Type  Conserved_site Description  Serpins (SERine Proteinase INhibitors) belong to MEROPS inhibitor family I4, clan ID. Most serpin family members are indeed serine protease inhibitors, but several have additional cross-class inhibition functions and inhibit cysteine protease family members such as the caspases and cathepsins [, ]. Others, such as ovalbumin, are incapable of protease inhibition and serve other functions []. Serpins share a highly conserved core structure that is critical for their functioning as serine protease inhibitors []. Inhibitory serpins comprise several alpha-helix and beta-strands together with an external reactive centre loop (RCL) containing the active site recognised by the target enzyme. Serpins form covalent complexes with target proteases. Their mechanism of protease inhibition is known as irreversible "trapping" , in which a rapid conformational change traps the cognate protease in a covalent complex.This entry represents a conserved site for the Serpin family of proteins, centred on a well conserved Pro-Phe sequence which is found ten to fifteen residues on the C-terminal side of the reactive bond.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS00284 PROSITE IPR023795

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

132 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087306 Q7K508 Drosophila melanogaster
FBpp0088124 Q8SYY7 Drosophila melanogaster
FBpp0099762 A1Z6V5 Drosophila melanogaster
FBpp0079094 Q9VLZ8 Drosophila melanogaster
FBpp0082596 Q9VFC2 Drosophila melanogaster
FBpp0088123 Q7JWX3 Drosophila melanogaster
FBpp0078950 Q9V3N1 Drosophila melanogaster
FBpp0110138 Q0E8V6 Drosophila melanogaster
FBpp0085497 Q8SZF4 Drosophila melanogaster
FBpp0289587 A1Z6R3 Drosophila melanogaster
FBpp0085912 Q7JV69 Drosophila melanogaster
FBpp0079179 Q9VLV3 Drosophila melanogaster
FBpp0300938 M9NEE3 Drosophila melanogaster
FBpp0085495 A1Z6R4 Drosophila melanogaster
FBpp0079528 Q9VL44 Drosophila melanogaster
FBpp0081649 Q9VH46 Drosophila melanogaster
FBpp0082594 Q9VFC1 Drosophila melanogaster
FBpp0282649 B5DVJ0 Drosophila pseudoobscura
FBpp0277131 B5E1C3 Drosophila pseudoobscura
FBpp0272035 B5DUW9 Drosophila pseudoobscura
FBpp0276691 Q290Q5 Drosophila pseudoobscura
FBpp0277113 Q292T9 Drosophila pseudoobscura
FBpp0277114 Q292U0 Drosophila pseudoobscura
FBpp0277115 Q292U1 Drosophila pseudoobscura
FBpp0277132 Q292X2 Drosophila pseudoobscura
FBpp0277334 Q292U3 Drosophila pseudoobscura
FBpp0277301 Q292X1 Drosophila pseudoobscura
FBpp0277303 B5E1C5 Drosophila pseudoobscura
FBpp0278494 B5E0M7 Drosophila pseudoobscura
FBpp0278766 Q28WR9 Drosophila pseudoobscura