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Protein Domain : IPR002109

Name  Glutaredoxin Short Name  Glutaredoxin
Type  Domain Description  Glutaredoxins [, , ], also known as thioltransferases (disulphide reductases, are small proteins of approximately one hundred amino-acid residues which utilise glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase. Together these components compose the glutathione system []. Glutaredoxin functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Like thioredoxin, which functions in a similar way, glutaredoxin possesses an active centre disulphide bond []. It exists in either a reduced or an oxidized form where the two cysteine residues are linked in an intramolecular disulphide bond.Glutaredoxin has been sequenced in a variety of species. On the basis of extensive sequence similarity, it has been proposed []that Vaccinia virusprotein O2L is mostprobably a glutaredoxin. Finally, it must be noted that Bacteriophage T4thioredoxin seems also to be evolutionary related. In position 5 of the pattern T4 thioredoxin has Val instead of Pro.This entry represents Glutaredoxin.

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR014025 Glutaredoxin subgroup Glutaredoxin_subgr Domain

1 Contains

DB identifier Name Short Name Type
IPR011767 Glutaredoxin active site GLR_AS Active_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00462 PFAM IPR002109
PS51354 PROFILE IPR002109

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

11 Found In

DB identifier Name Short Name Type
IPR012336 Thioredoxin-like fold Thioredoxin-like_fold Domain
IPR014434 Monothiol glutaredoxin Monothiol_GRX Family
IPR004480 Monothiol glutaredoxin-related Monothiol_GRX-rel Family
IPR011915 Glutaredoxin-like protein, actinobacteria GlrX_actino Family
IPR011902 Glutaredoxin, GrxA GRXA Family
IPR011900 Glutaredoxin, GrxC GRX_bact Family
IPR004502 Thioredoxins/glutaredoxin Thio_glut Family
IPR011909 Glutaredoxin-like protein NrdH GlrX_NrdH Family
IPR011905 Glutaredoxin-like, plant II GlrX-like_pln_2 Family
IPR011903 Glutaredoxin-like domain Glutaredoxin-like_dom Family
IPR011911 Glutaredoxin-like protein, YruB GlrX_YruB Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Glutaredoxin   GO:0009055 electron carrier activity
Glutaredoxin   GO:0015035 protein disulfide oxidoreductase activity
Glutaredoxin   GO:0045454 cell redox homeostasis

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Glutaredoxin   GO:0009055 electron carrier activity
Glutaredoxin   GO:0015035 protein disulfide oxidoreductase activity
Glutaredoxin   GO:0045454 cell redox homeostasis

0 Parent Features

108 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070503 Q9W4S1 Drosophila melanogaster
FBpp0080044 Q9VJZ6 Drosophila melanogaster
FBpp0073806 Q8SXQ5 Drosophila melanogaster
FBpp0071631 Q9W2D1 Drosophila melanogaster
FBpp0075118 Q9V420 Drosophila melanogaster
FBpp0078265 Q9VNL4 Drosophila melanogaster
FBpp0074830 Q9VVT6 Drosophila melanogaster
FBpp0279030 Q29P85 Drosophila pseudoobscura
FBpp0278484 Q28XR2 Drosophila pseudoobscura
FBpp0272679 B5DLJ2 Drosophila pseudoobscura
FBpp0272833 Q29IT3 Drosophila pseudoobscura
FBpp0274511 Q2M0E0 Drosophila pseudoobscura
FBpp0284085 Q297Y2 Drosophila pseudoobscura
FBpp0286004 Q29D53 Drosophila pseudoobscura
FBpp0162700 B4KYZ8 Drosophila mojavensis
FBpp0163555 B4L8L4 Drosophila mojavensis
FBpp0165629 B4L6R1 Drosophila mojavensis
FBpp0165929 B4L9S2 Drosophila mojavensis
FBpp0166430 B4KK55 Drosophila mojavensis
FBpp0167948 B4KNS2 Drosophila mojavensis
FBpp0172395 B4KB07 Drosophila mojavensis
FBpp0233809 B4M1X2 Drosophila virilis
FBpp0226261 B4LD58 Drosophila virilis
FBpp0226873 B4LCY4 Drosophila virilis
FBpp0228908 B4MBR6 Drosophila virilis
FBpp0231450 B4M7Q3 Drosophila virilis
FBpp0232386 B4M976 Drosophila virilis
FBpp0236168 B4LLQ0 Drosophila virilis
FBpp0257231 B4P8F1 Drosophila yakuba
FBpp0261108 B4PW73 Drosophila yakuba