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Protein Domain : IPR001711

Name  Phospholipase C, phosphatidylinositol-specific, Y domain Short Name  PLipase_C_Pinositol-sp_Y
Type  Domain Description  Phosphatidylinositol-specific phospholipase C (), an eukaryotic intracellular enzyme, plays an important role in signal transduction processes [](see ). It catalyzes the hydrolysis of 1-phosphatidyl-D-myo-inositol-3,4,5-triphosphate into the second messenger molecules diacylglycerol and inositol-1,4,5-triphosphate. This catalytic process is tightly regulated by reversible phosphorylation and binding of regulatory proteins [, , ].In mammals, there are at least 6 different isoforms of PI-PLC, they differ in their domain structure, their regulation, and their tissue distribution. Lower eukaryotes also possess multiple isoforms of PI-PLC.All eukaryotic PI-PLCs contain two regions of homology, sometimes referred to as 'X-box' (see ) and 'Y-box'. The order of these two regions is always the same (NH2-X-Y-COOH), but the spacing is variable. In most isoforms, the distance between these two regions is only 50-100 residues but in the gamma isoforms one PH domain, two SH2 domains, and one SH3 domain are inserted between the two PLC-specific domains. The two conserved regions have been shown to be important for the catalytic activity. At the C-terminal of the Y-box, there is a C2 domain (see ) possibly involved in Ca-dependent membrane attachment.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00387 PFAM IPR001711
PS50008 PROFILE IPR001711
SM00149 SMART IPR001711

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

4 Found In

DB identifier Name Short Name Type
IPR001192 Phosphoinositide phospholipase C family PI-PLC_fam Family
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain PLC-like_Pdiesterase_TIM-brl Domain
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma PLC-gamma Family
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta PLC-beta Family

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phospholipase C, phosphatidylinositol-specific, Y domain   GO:0004435 phosphatidylinositol phospholipase C activity
Phospholipase C, phosphatidylinositol-specific, Y domain   GO:0006629 lipid metabolic process
Phospholipase C, phosphatidylinositol-specific, Y domain   GO:0007165 signal transduction
Phospholipase C, phosphatidylinositol-specific, Y domain   GO:0035556 intracellular signal transduction

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phospholipase C, phosphatidylinositol-specific, Y domain   GO:0004435 phosphatidylinositol phospholipase C activity
Phospholipase C, phosphatidylinositol-specific, Y domain   GO:0006629 lipid metabolic process
Phospholipase C, phosphatidylinositol-specific, Y domain   GO:0007165 signal transduction
Phospholipase C, phosphatidylinositol-specific, Y domain   GO:0035556 intracellular signal transduction

0 Parent Features

76 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070619 P13217 Drosophila melanogaster
FBpp0074009 Q9VXH3 Drosophila melanogaster
FBpp0089226 P25455 Drosophila melanogaster
FBpp0274154 B5DNH4 Drosophila pseudoobscura
FBpp0272951 Q29J49 Drosophila pseudoobscura
FBpp0280181 Q29N33 Drosophila pseudoobscura
FBpp0163674 B4L8R0 Drosophila mojavensis
FBpp0165388 B4L6I9 Drosophila mojavensis
FBpp0165389 B4L6I8 Drosophila mojavensis
FBpp0165628 B4L6Q9 Drosophila mojavensis
FBpp0172327 B4KL19 Drosophila mojavensis
FBpp0231449 B4M7Q2 Drosophila virilis
FBpp0233208 Q86RA6 Drosophila virilis
FBpp0238037 B4LUP2 Drosophila virilis
FBpp0261351 B4Q064 Drosophila yakuba
FBpp0261757 B4P2C8 Drosophila yakuba
FBpp0262274 B4PXS1 Drosophila yakuba
A8XRA5_CAEBR A8XRA5 Caenorhabditis briggsae
A8XQR6_CAEBR A8XQR6 Caenorhabditis briggsae
A8XTL0_CAEBR A8XTL0 Caenorhabditis briggsae
A8X232_CAEBR A8X232 Caenorhabditis briggsae
A8X1E0_CAEBR A8X1E0 Caenorhabditis briggsae
A8XTZ1_CAEBR A8XTZ1 Caenorhabditis briggsae
A8XMK5_CAEBR A8XMK5 Caenorhabditis briggsae
K7GXC6_CAEJA K7GXC6 Caenorhabditis japonica
K7GXC5_CAEJA K7GXC5 Caenorhabditis japonica
K7GVW8_CAEJA K7GVW8 Caenorhabditis japonica
K7GVW7_CAEJA K7GVW7 Caenorhabditis japonica
K7GXC4_CAEJA K7GXC4 Caenorhabditis japonica
K7GVX0_CAEJA K7GVX0 Caenorhabditis japonica