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Protein Domain : IPR017946

Name  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain Short Name  PLC-like_Pdiesterase_TIM-brl
Type  Domain Description  This entry represents a structural domain consisting of a TIM beta/alpha-barrel. These domains are found in several phospholipase C (PLC) like phosphodiesterases, including:Mammalian phospholipase C isozyme D1 [].Bacterial phosphatidylinositol-specific phospholipase C [].Glycerophosphodiester phosphodiesterases, such as GlpQ from Escherichia coliand UgpQ from Agrobacterium tumefaciens[].Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. PLC enzymes often play central roles in various signalling cascades [].

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain PLipase_C_PInositol-sp_X_dom Domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain PLipase_C_Pinositol-sp_Y Domain
IPR003633 Phospholipase C, variant-surface-glycoprotein PLipase_C_var-glycoprot Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:3.20.20.190 GENE3D IPR017946
SSF51695 SSF IPR017946

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

4 Found In

DB identifier Name Short Name Type
IPR001192 Phosphoinositide phospholipase C family PI-PLC_fam Family
IPR004129 Glycerophosphoryl diester phosphodiesterase GlyceroP-diester-Pdiesterase Family
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma PLC-gamma Family
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta PLC-beta Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain   GO:0008081 phosphoric diester hydrolase activity
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain   GO:0006629 lipid metabolic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain   GO:0008081 phosphoric diester hydrolase activity
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain   GO:0006629 lipid metabolic process

0 Parent Features

176 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074813 Q9VVV4 Drosophila melanogaster
FBpp0082033 Q9VGB2 Drosophila melanogaster
FBpp0080873 Q9VIP3 Drosophila melanogaster
FBpp0070619 P13217 Drosophila melanogaster
FBpp0079878 Q9VKC3 Drosophila melanogaster
FBpp0075195 Q9VUX4 Drosophila melanogaster
FBpp0082742 Q9VEU9 Drosophila melanogaster
FBpp0305791 E1JI10 Drosophila melanogaster
FBpp0077226 Q9VQU3 Drosophila melanogaster
FBpp0077227 Q8IQ03 Drosophila melanogaster
FBpp0074009 Q9VXH3 Drosophila melanogaster
FBpp0074811 Q86BJ0 Drosophila melanogaster
FBpp0074809 Q9VVV5 Drosophila melanogaster
FBpp0074810 Q9VVV6 Drosophila melanogaster
FBpp0074812 Q86BI9 Drosophila melanogaster
FBpp0089226 P25455 Drosophila melanogaster
FBpp0071495 Q9W2L6 Drosophila melanogaster
FBpp0304897 M9PI96 Drosophila melanogaster
FBpp0274154 B5DNH4 Drosophila pseudoobscura
FBpp0272951 Q29J49 Drosophila pseudoobscura
FBpp0279973 Q29MF0 Drosophila pseudoobscura
FBpp0274688 Q2M102 Drosophila pseudoobscura
FBpp0278689 Q28X19 Drosophila pseudoobscura
FBpp0280181 Q29N33 Drosophila pseudoobscura
FBpp0284436 Q296D0 Drosophila pseudoobscura
FBpp0284535 Q295R1 Drosophila pseudoobscura
FBpp0285151 Q29NJ8 Drosophila pseudoobscura
FBpp0286130 Q29DJ4 Drosophila pseudoobscura
FBpp0286132 Q29DJ5 Drosophila pseudoobscura
FBpp0287864 Q29KK9 Drosophila pseudoobscura