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Protein Domain : IPR001791

Name  Laminin G domain Short Name  Laminin_G
Type  Domain Description  Laminins are large heterotrimeric glycoproteins involved in basement membrane function []. The Laminin G or LNS domain (for Laminin-alpha, Neurexin and Sex hormone-binding globulin) is an around 180 amino acid long domain found in a large and diverse set of extracellular proteins [, ]. The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. The C terminus of the laminin alpha chain contains a tandem repeat of five laminin G domains, which are critical for heparin-binding and cell attachment activity []. Laminin alpha4 is distributed in a variety of tissues including peripheral nerves, dorsal root ganglion, skeletal muscle and capillaries; in the neuromuscular junction, it is required for synaptic specialisation []. The structure of the laminin-G domain has been predicted to resemble that of pentraxin [].Laminin G domains can vary in their function, and a variety of binding functions have been ascribed to different LamG modules. For example, the laminin alpha1 and alpha2 chains each have five C-teminal laminin G domains, where only domains LG4 and LG5contain binding sites for heparin, sulphatides and the cell surface receptor dystroglycan []. Laminin G-containing proteins appear to have a wide variety of roles in cell adhesion, signalling, migration, assembly and differentiation. Proteins with laminin-G domains include:Laminin.Merosin.Agrin.Neurexins.Vitamin K dependent protein S.Sex steroid binding protein SBP/SHBG.Drosophila proteins Slit, Crumbs, Fat.several proteoglycan precursors.

Publication Counts Displayer

0 Child Features

0 Contains

5 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00054 PFAM IPR001791
PF02210 PFAM IPR001791
PS50025 PROFILE IPR001791
SM00210 SMART IPR001791
SM00282 SMART IPR001791

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR013320 Concanavalin A-like lectin/glucanase, subgroup ConA-like_subgrp Domain

270 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0291871 Q8IP51 Drosophila melanogaster
FBpp0293600 R9PY40 Drosophila melanogaster
FBpp0291872 M9MRU0 Drosophila melanogaster
FBpp0099719 Q4ABE9 Drosophila melanogaster
FBpp0099718 Q4ABF0 Drosophila melanogaster
FBpp0080568 O15943 Drosophila melanogaster
FBpp0099721 Q4ABE7 Drosophila melanogaster
FBpp0099720 Q4ABE8 Drosophila melanogaster
FBpp0075730 Q94887 Drosophila melanogaster
FBpp0077167 P33450 Drosophila melanogaster
FBpp0081905 Q9VGJ0 Drosophila melanogaster
FBpp0071475 Q24298 Drosophila melanogaster
FBpp0083649 Q9VCZ9 Drosophila melanogaster
FBpp0292315 Q9V5N8 Drosophila melanogaster
FBpp0086351 A1ZA87 Drosophila melanogaster
FBpp0083987 P10040 Drosophila melanogaster
FBpp0303575 P24014 Drosophila melanogaster
FBpp0300935 Q9VJB6 Drosophila melanogaster
FBpp0304601 Q9VJ82 Drosophila melanogaster
FBpp0290335 E1JIE2 Drosophila melanogaster
FBpp0290327 E1JIE1 Drosophila melanogaster
FBpp0290336 E1JIE0 Drosophila melanogaster
FBpp0290330 E1JID9 Drosophila melanogaster
FBpp0301686 M9ND55 Drosophila melanogaster
FBpp0297593 E1JIE3 Drosophila melanogaster
FBpp0289805 E1JH30 Drosophila melanogaster
FBpp0075731 Q8IQH0 Drosophila melanogaster
FBpp0290700 Q3KN41 Drosophila melanogaster
FBpp0297316 M9NF15 Drosophila melanogaster
FBpp0297315 M9PE65 Drosophila melanogaster