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Protein Domain : IPR000798

Name  Ezrin/radixin/moesin like Short Name  Ez/rad/moesin_like
Type  Family Description  The ERM family consists of three closely-related proteins, ezrin, radixin and moesin [].Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparinbinding protein []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2)is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein).ERM molecules contain 3 domains, an N-terminal globular domain; an extended alpha-helical domain; and acharged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region betweenthe helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin,band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins crosslink actin filaments withplasma membranes. They co-localise with CD44 at actin filament-plasma membrane interaction sites,associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains[].

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR011174 Ezrin/radixin/moesin ERM Family
IPR021187 Band 4.1 protein Band_41_protein Family

12 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle FERM/acyl-CoA-bd_prot_3-hlx Domain
IPR019748 FERM central domain FERM_central Domain
IPR000299 FERM domain FERM_domain Domain
IPR018979 FERM, N-terminal FERM_N Domain
IPR014847 FERM adjacent (FA) FERM-adjacent Domain
IPR019747 FERM conserved site FERM_CS Conserved_site
IPR018980 FERM, C-terminal PH-like domain FERM_PH-like_C Domain
IPR011259 Ezrin/radixin/moesin, C-terminal ERM_C_dom Domain
IPR008954 Moesin tail domain Moesin_tail Domain
IPR008379 Band 4.1, C-terminal Band_4.1_C Domain
IPR007477 SAB domain SAB_dom Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR00661 PRINTS IPR000798

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ezrin/radixin/moesin like   GO:0008092 cytoskeletal protein binding
Ezrin/radixin/moesin like   GO:0005737 cytoplasm
Ezrin/radixin/moesin like   GO:0019898 extrinsic component of membrane

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ezrin/radixin/moesin like   GO:0008092 cytoskeletal protein binding
Ezrin/radixin/moesin like   GO:0005737 cytoplasm
Ezrin/radixin/moesin like   GO:0019898 extrinsic component of membrane

1 Parent Features

DB identifier Name Short Name Type
IPR019750 Band 4.1 family Band_41_fam Family

75 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0082261 Q9VFU8 Drosophila melanogaster
FBpp0089236 P46150 Drosophila melanogaster
FBpp0074523 Q24564 Drosophila melanogaster
FBpp0079589 Q9VKY7 Drosophila melanogaster
FBpp0290494 H5V8A7 Drosophila melanogaster
FBpp0303991 M9PHG2 Drosophila melanogaster
FBpp0300513 C7LAH9 Drosophila melanogaster
FBpp0112924 A0T1Z5 Drosophila melanogaster
FBpp0112923 A0T1Z4 Drosophila melanogaster
FBpp0112925 B7Z0J2 Drosophila melanogaster
FBpp0307779 Q9VN68 Drosophila melanogaster
FBpp0307778 Q2M1E6 Drosophila melanogaster
FBpp0300693 B5DY71 Drosophila pseudoobscura
FBpp0309093 Q28Z97 Drosophila pseudoobscura
FBpp0309094 N6WBW7 Drosophila pseudoobscura
FBpp0285901 Q29CW6 Drosophila pseudoobscura
FBpp0308184 N6VF07 Drosophila pseudoobscura
FBpp0308185 N6V854 Drosophila pseudoobscura
FBpp0298812 I5AP30 Drosophila pseudoobscura
FBpp0281848 Q297Q7 Drosophila pseudoobscura
FBpp0298810 I5AP28 Drosophila pseudoobscura
FBpp0298811 I5AP29 Drosophila pseudoobscura
FBpp0284534 Q29HY4 Drosophila pseudoobscura
FBpp0160236 B4L7Z7 Drosophila mojavensis
FBpp0159465 B4KDC3 Drosophila mojavensis
FBpp0164784 B4L3K2 Drosophila mojavensis
FBpp0168135 B4KU65 Drosophila mojavensis
FBpp0169607 B4KHT0 Drosophila mojavensis
FBpp0225470 B4M543 Drosophila virilis
FBpp0228159 B4LVD7 Drosophila virilis