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Protein Domain : IPR011259

Name  Ezrin/radixin/moesin, C-terminal Short Name  ERM_C_dom
Type  Domain Description  The ERM family consists of three closely-related proteins, ezrin, radixin and moesin [].Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparinbinding protein []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2)is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein).ERM molecules contain 3 domains, an N-terminal globular domain; an extended alpha-helical domain; and acharged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region betweenthe helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin,band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins crosslink actin filaments withplasma membranes. They co-localise with CD44 at actin filament-plasma membrane interaction sites,associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains[].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR008954 Moesin tail domain Moesin_tail Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00769 PFAM IPR011259

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

3 Found In

DB identifier Name Short Name Type
IPR011174 Ezrin/radixin/moesin ERM Family
IPR000798 Ezrin/radixin/moesin like Ez/rad/moesin_like Family
IPR015788 Moesin/ezrin/radixin homologue 2 EMR2 Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ezrin/radixin/moesin, C-terminal   GO:0008092 cytoskeletal protein binding
Ezrin/radixin/moesin, C-terminal   GO:0005737 cytoplasm
Ezrin/radixin/moesin, C-terminal   GO:0019898 extrinsic component of membrane

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ezrin/radixin/moesin, C-terminal   GO:0008092 cytoskeletal protein binding
Ezrin/radixin/moesin, C-terminal   GO:0005737 cytoplasm
Ezrin/radixin/moesin, C-terminal   GO:0019898 extrinsic component of membrane

0 Parent Features

23 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0089236 P46150 Drosophila melanogaster
FBpp0074523 Q24564 Drosophila melanogaster
FBpp0303991 M9PHG2 Drosophila melanogaster
FBpp0300513 C7LAH9 Drosophila melanogaster
FBpp0284534 Q29HY4 Drosophila pseudoobscura
FBpp0160236 B4L7Z7 Drosophila mojavensis
FBpp0164784 B4L3K2 Drosophila mojavensis
FBpp0229596 B4MD92 Drosophila virilis
FBpp0230035 B4MAR0 Drosophila virilis
FBpp0262370 B4PZD7 Drosophila yakuba
FBpp0262441 B4Q005 Drosophila yakuba
A8XFS2_CAEBR A8XFS2 Caenorhabditis briggsae
H2VYF0_CAEJA H2VYF0 Caenorhabditis japonica
G0NHD6_CAEBE G0NHD6 Caenorhabditis brenneri
G5EGU8_CAEEL G5EGU8 Caenorhabditis elegans
G5EBK3_CAEEL G5EBK3 Caenorhabditis elegans
G5EES2_CAEEL G5EES2 Caenorhabditis elegans
MOEH_DROME-5 P46150-5 Drosophila melanogaster
MOEH_DROME-2 P46150-2 Drosophila melanogaster
MOEH_DROME-4 P46150-4 Drosophila melanogaster
MOEH_DROME-3 P46150-3 Drosophila melanogaster
E3LMK9_CAERE E3LMK9 Caenorhabditis remanei
MOEH_DROPS Q29GR8 Drosophila pseudoobscura