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Protein Domain : IPR011259

Name	Ezrin/radixin/moesin, C-terminal	Short Name	ERM_C_dom
Type	Domain	Description	The ERM family consists of three closely-related proteins, ezrin, radixin and moesin [].Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparinbinding protein []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2)is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein).ERM molecules contain 3 domains, an N-terminal globular domain; an extended alpha-helical domain; and acharged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region betweenthe helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin,band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins crosslink actin filaments withplasma membranes. They co-localise with CD44 at actin filament-plasma membrane interaction sites,associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains[].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier	Name	Short Name	Type
IPR008954	Moesin tail domain	Moesin_tail	Domain

1 Cross References

Identifier	Source . Name	Subject . Primary Identifier
PF00769	PFAM	IPR011259

3 Data Sets

Name	URL
TrEMBL data set	http://www.ebi.ac.uk/trembl/
InterPro data set
InterPro GO Annotation data set

3 Found In

DB identifier	Name	Short Name	Type
IPR011174	Ezrin/radixin/moesin	ERM	Family
IPR000798	Ezrin/radixin/moesin like	Ez/rad/moesin_like	Family
IPR015788	Moesin/ezrin/radixin homologue 2	EMR2	Family

3 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Ezrin/radixin/moesin, C-terminal		GO:0008092	cytoskeletal protein binding
	Ezrin/radixin/moesin, C-terminal		GO:0005737	cytoplasm
	Ezrin/radixin/moesin, C-terminal		GO:0019898	extrinsic component of membrane

3 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Ezrin/radixin/moesin, C-terminal		GO:0008092	cytoskeletal protein binding
	Ezrin/radixin/moesin, C-terminal		GO:0005737	cytoplasm
	Ezrin/radixin/moesin, C-terminal		GO:0019898	extrinsic component of membrane

0 Parent Features

23 Proteins

DB identifier	Primary Accession	Organism . Name
FBpp0089236	P46150	Drosophila melanogaster
FBpp0074523	Q24564	Drosophila melanogaster
FBpp0303991	M9PHG2	Drosophila melanogaster
FBpp0300513	C7LAH9	Drosophila melanogaster
FBpp0284534	Q29HY4	Drosophila pseudoobscura
FBpp0160236	B4L7Z7	Drosophila mojavensis
FBpp0164784	B4L3K2	Drosophila mojavensis
FBpp0229596	B4MD92	Drosophila virilis
FBpp0230035	B4MAR0	Drosophila virilis
FBpp0262370	B4PZD7	Drosophila yakuba
FBpp0262441	B4Q005	Drosophila yakuba
A8XFS2_CAEBR	A8XFS2	Caenorhabditis briggsae
H2VYF0_CAEJA	H2VYF0	Caenorhabditis japonica
G0NHD6_CAEBE	G0NHD6	Caenorhabditis brenneri
G5EGU8_CAEEL	G5EGU8	Caenorhabditis elegans
G5EBK3_CAEEL	G5EBK3	Caenorhabditis elegans
G5EES2_CAEEL	G5EES2	Caenorhabditis elegans
MOEH_DROME-5	P46150-5	Drosophila melanogaster
MOEH_DROME-2	P46150-2	Drosophila melanogaster
MOEH_DROME-4	P46150-4	Drosophila melanogaster
MOEH_DROME-3	P46150-3	Drosophila melanogaster
E3LMK9_CAERE	E3LMK9	Caenorhabditis remanei
MOEH_DROPS	Q29GR8	Drosophila pseudoobscura

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