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Protein Domain : IPR011174

Name  Ezrin/radixin/moesin Short Name  ERM
Type  Family Description  This group represents an ezrin/radixin/moesin. The ERM family consists of three closely-related proteins, ezrin, radixin and moesin [].Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparinbinding protein []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2)is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein).ERM molecules contain 3 domains, an N-terminal globular domain; an extended alpha-helical domain; and acharged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region betweenthe helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin,band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins crosslink actin filaments withplasma membranes. They co-localise with CD44 at actin filament-plasma membrane interaction sites,associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains[].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR015788 Moesin/ezrin/radixin homologue 2 EMR2 Family

9 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR019748 FERM central domain FERM_central Domain
IPR000299 FERM domain FERM_domain Domain
IPR018979 FERM, N-terminal FERM_N Domain
IPR019747 FERM conserved site FERM_CS Conserved_site
IPR018980 FERM, C-terminal PH-like domain FERM_PH-like_C Domain
IPR011259 Ezrin/radixin/moesin, C-terminal ERM_C_dom Domain
IPR008954 Moesin tail domain Moesin_tail Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF002305 PIRSF IPR011174

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ezrin/radixin/moesin   GO:0008092 cytoskeletal protein binding
Ezrin/radixin/moesin   GO:0005737 cytoplasm
Ezrin/radixin/moesin   GO:0019898 extrinsic component of membrane

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ezrin/radixin/moesin   GO:0008092 cytoskeletal protein binding
Ezrin/radixin/moesin   GO:0005737 cytoplasm
Ezrin/radixin/moesin   GO:0019898 extrinsic component of membrane

1 Parent Features

DB identifier Name Short Name Type
IPR000798 Ezrin/radixin/moesin like Ez/rad/moesin_like Family

27 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0089236 P46150 Drosophila melanogaster
FBpp0074523 Q24564 Drosophila melanogaster
FBpp0303991 M9PHG2 Drosophila melanogaster
FBpp0300513 C7LAH9 Drosophila melanogaster
FBpp0284534 Q29HY4 Drosophila pseudoobscura
FBpp0160236 B4L7Z7 Drosophila mojavensis
FBpp0164784 B4L3K2 Drosophila mojavensis
FBpp0229596 B4MD92 Drosophila virilis
FBpp0230035 B4MAR0 Drosophila virilis
FBpp0262370 B4PZD7 Drosophila yakuba
FBpp0262441 B4Q005 Drosophila yakuba
A8XFS2_CAEBR A8XFS2 Caenorhabditis briggsae
H2WBW8_CAEJA H2WBW8 Caenorhabditis japonica
H2VYF0_CAEJA H2VYF0 Caenorhabditis japonica
G0NHD6_CAEBE G0NHD6 Caenorhabditis brenneri
G0N2N7_CAEBE G0N2N7 Caenorhabditis brenneri
G5EGU8_CAEEL G5EGU8 Caenorhabditis elegans
G5EBK3_CAEEL G5EBK3 Caenorhabditis elegans
G5EES2_CAEEL G5EES2 Caenorhabditis elegans
H2KYX2_CAEEL H2KYX2 Caenorhabditis elegans
Q5LK46_CAEEL Q5LK46 Caenorhabditis elegans
MOEH_DROME-5 P46150-5 Drosophila melanogaster
MOEH_DROME-2 P46150-2 Drosophila melanogaster
MOEH_DROME-4 P46150-4 Drosophila melanogaster
MOEH_DROME-3 P46150-3 Drosophila melanogaster
E3LMK9_CAERE E3LMK9 Caenorhabditis remanei
MOEH_DROPS Q29GR8 Drosophila pseudoobscura