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Protein Domain : IPR015482

Name  Syntrophin Short Name  Syntrophin
Type  Family Description  The syntrophin family are intracellular membrane-associated proteins that interact with both ion channels and signalling proteins. As such, syntrophins appear to be important for linking ion channels to intracellular signalling pathways. Syntrophins are concentrated at postsynaptic sites at the neuromuscular junction and may be involved in clustering acetylcholine receptors. In muscle and non-muscle tissues, syntrophin is associated with dystrophin, utrophin, and two homologues of the dystrophin carboxy-terminal region [].The five known syntrophin isoforms share a common domain organisation which includes two tandem pleckstrin homology (PH) domains at the N terminus, a PDZ domain and a C-terminal domain of ~70 amino acids that is unique to syntrophins (syntrophin unique, SU) [].

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR028550 Beta-2-syntrophin SNTB2 Family
IPR015483 Gamma 1 syntrophin Syntrophin_gamma Family
IPR028552 Alpha-1-syntrophin SNTA1 Family

2 Contains

DB identifier Name Short Name Type
IPR001849 Pleckstrin homology domain Pleckstrin_homology Domain
IPR001478 PDZ domain PDZ Domain

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

32 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0306025 Q9VNY4 Drosophila melanogaster
FBpp0078104 Q9VNY2 Drosophila melanogaster
FBpp0302599 M9PGE3 Drosophila melanogaster
FBpp0086240 Q8SX22 Drosophila melanogaster
FBpp0086242 Q0E952 Drosophila melanogaster
FBpp0086244 A1ZAH3 Drosophila melanogaster
FBpp0275088 Q2M0B5 Drosophila pseudoobscura
FBpp0276915 Q291U2 Drosophila pseudoobscura
FBpp0162956 B4KUV6 Drosophila mojavensis
FBpp0169747 B4KSI4 Drosophila mojavensis
FBpp0228501 B4LD77 Drosophila virilis
FBpp0236796 B4LMF1 Drosophila virilis
FBpp0256812 B4P657 Drosophila yakuba
FBpp0267305 B4PD37 Drosophila yakuba
FBpp0268001 B4ITC3 Drosophila yakuba
A8WKU4_CAEBR A8WKU4 Caenorhabditis briggsae
A8XPR7_CAEBR A8XPR7 Caenorhabditis briggsae
K7GV07_CAEJA K7GV07 Caenorhabditis japonica
H2W4S7_CAEJA H2W4S7 Caenorhabditis japonica
K7GV08_CAEJA K7GV08 Caenorhabditis japonica
G0MFT1_CAEBE G0MFT1 Caenorhabditis brenneri
G0PCU6_CAEBE G0PCU6 Caenorhabditis brenneri
G0MWK0_CAEBE G0MWK0 Caenorhabditis brenneri
SNT1_CAEEL Q93646 Caenorhabditis elegans
SNT1_CAEEL-2 Q93646-2 Caenorhabditis elegans
Q5WRR6_CAEEL Q5WRR6 Caenorhabditis elegans
H2KZE9_CAEEL H2KZE9 Caenorhabditis elegans
Q9GT68_DROME Q9GT68 Drosophila melanogaster
D3PFI3_DROME D3PFI3 Drosophila melanogaster
E3CTN9_DROME E3CTN9 Drosophila melanogaster