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Protein Domain : IPR010472

Name  Formin, FH3 domain Short Name  FH3_dom
Type  Domain Description  Formin homology (FH) proteins play a crucial role in the reorganisation of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis []. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains []. The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The FH2 domain () is required to inhibit actin polymerisation. The FH3 domain is less well conserved and is required for directing formins to the correct intracellular location, such the mitotic spindle [], or the projection tip during conjugation []. In addition, some formins can contain a GTPase-binding domain (GBD) () required for binding to Rho small GTPases, and a C-terminal conserved Dia-autoregulatory domain (DAD).This entry represents the FH3 domain.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF06367 PFAM IPR010472

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR014768 Formin, GTPase-binding and FH3 domain GTPase-bd/formin_homology_3 Domain

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Formin, FH3 domain   GO:0003779 actin binding
Formin, FH3 domain   GO:0016043 cellular component organization

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Formin, FH3 domain   GO:0003779 actin binding
Formin, FH3 domain   GO:0016043 cellular component organization

0 Parent Features

60 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070229 Q8IRY0 Drosophila melanogaster
FBpp0070231 Q7YZA4 Drosophila melanogaster
FBpp0112380 A8JNM1 Drosophila melanogaster
FBpp0099826 Q86C16 Drosophila melanogaster
FBpp0303810 M9PDL4 Drosophila melanogaster
FBpp0303809 Q9W0J2 Drosophila melanogaster
FBpp0080941 P48608 Drosophila melanogaster
FBpp0292356 M9MSM5 Drosophila melanogaster
FBpp0307717 M9PE53 Drosophila melanogaster
FBpp0075517 Q9VUC6 Drosophila melanogaster
FBpp0297103 M9NCZ5 Drosophila melanogaster
FBpp0306179 M9PCF8 Drosophila melanogaster
FBpp0274637 B5DPB2 Drosophila pseudoobscura
FBpp0286520 Q29EU7 Drosophila pseudoobscura
FBpp0273436 Q29IY8 Drosophila pseudoobscura
FBpp0275108 Q2M082 Drosophila pseudoobscura
FBpp0279807 Q29LX2 Drosophila pseudoobscura
FBpp0162509 B4KWB7 Drosophila mojavensis
FBpp0162977 B4KV62 Drosophila mojavensis
FBpp0165666 B4L6Z1 Drosophila mojavensis
FBpp0165981 B4L919 Drosophila mojavensis
FBpp0167138 B4KEC8 Drosophila mojavensis
FBpp0226475 B4LHK6 Drosophila virilis
FBpp0226926 B4LCC6 Drosophila virilis
FBpp0228167 B4LFZ3 Drosophila virilis
FBpp0230266 B4MA64 Drosophila virilis
FBpp0232110 B4LST4 Drosophila virilis
FBpp0257355 B4P6K3 Drosophila yakuba
FBpp0261545 B4PXN0 Drosophila yakuba
FBpp0266137 B4PD50 Drosophila yakuba