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Protein Domain : IPR016158

Name  Cullin homology Short Name  Cullin_homology
Type  Domain Description  Cullins are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). Cullins are found throughout eukaryotes. Humans express seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), each forming part of a multi-subunit ubiquitin complex. Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) [], play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as the APC2 subunit of the anaphase-promoting complex/cyclosome and the p53 cytoplasmic anchor PARC; both APC2 and PARC have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins [, , ].This entry represents the cullin homology region, which is composed of three domains: a 4-helical bundle domain, an alpha+beta domain, and a winged helix-like domain.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Source . Name

Subject . Primary Identifier
PS50069 PROFILE IPR016158
SM00182 SMART IPR016158
SSF75632 SSF IPR016158

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

1 Found In

DB identifier Name Short Name Type
IPR001373 Cullin, N-terminal Cullin_N Domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

86 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0072065 Q9W1E5 Drosophila melanogaster
FBpp0087921 Q24311 Drosophila melanogaster
FBpp0075633 Q9VU33 Drosophila melanogaster
FBpp0291367 Q9V475 Drosophila melanogaster
FBpp0085255 Q9V9R2 Drosophila melanogaster
FBpp0291369 Q8IP45 Drosophila melanogaster
FBpp0290569 Q5BI50 Drosophila melanogaster
FBpp0084786 Q9VAQ0 Drosophila melanogaster
FBpp0274492 Q2M0C4 Drosophila pseudoobscura
FBpp0277856 Q290C0 Drosophila pseudoobscura
FBpp0277897 Q28ZW7 Drosophila pseudoobscura
FBpp0279434 Q29P05 Drosophila pseudoobscura
FBpp0283889 Q299A0 Drosophila pseudoobscura
FBpp0287799 Q29KT9 Drosophila pseudoobscura
FBpp0307544 Q28YB0 Drosophila pseudoobscura
FBpp0166659 B4KF20 Drosophila mojavensis
FBpp0169003 B4KQ35 Drosophila mojavensis
FBpp0169492 B4KNX2 Drosophila mojavensis
FBpp0169919 B4KLY2 Drosophila mojavensis
FBpp0171943 B4KLG3 Drosophila mojavensis
FBpp0172627 B4K7W9 Drosophila mojavensis
FBpp0225033 B4M5P4 Drosophila virilis
FBpp0228647 B4LUQ0 Drosophila virilis
FBpp0232167 B4ME02 Drosophila virilis
FBpp0234645 B4LJM1 Drosophila virilis
FBpp0236307 B4LP09 Drosophila virilis
FBpp0237705 B4LV44 Drosophila virilis
FBpp0255490 B4PQ77 Drosophila yakuba
FBpp0257934 B4P6G6 Drosophila yakuba
FBpp0259363 B4PAB8 Drosophila yakuba