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Protein Domain : IPR000842

Name  Phosphoribosyl pyrophosphate synthetase, conserved site Short Name  PRib_PP_synth_CS
Type  Conserved_site Description  Phosphoribosyl pyrophosphate synthetase () (PRib-PP synthetase) catalyses the formation of PRib-PP from ATP and ribose 5-phosphate. PRib-PP is then used in various biosynthetic pathways, for example in the formation of purines, pyrimidines, histidine and tryptophan. PRib-PP synthetase requires inorganic phosphate and magnesium ions for its stability and activity. In mammals, three isozymes of PRib-PP synthetase are found, while in yeast there are at least four isozymes. A very conserved region containing two conserved aspartic acid residues as well as a histidine has been suggested to be involved in binding divalent cations []. These residues are all potential ligands for a cation such as magnesium.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00114 PROSITE IPR000842

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR005946 Ribose-phosphate diphosphokinase Rib-P_diPkinase Family

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphoribosyl pyrophosphate synthetase, conserved site   GO:0000287 magnesium ion binding
Phosphoribosyl pyrophosphate synthetase, conserved site   GO:0004749 ribose phosphate diphosphokinase activity
Phosphoribosyl pyrophosphate synthetase, conserved site   GO:0009156 ribonucleoside monophosphate biosynthetic process
Phosphoribosyl pyrophosphate synthetase, conserved site   GO:0044249 cellular biosynthetic process

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphoribosyl pyrophosphate synthetase, conserved site   GO:0000287 magnesium ion binding
Phosphoribosyl pyrophosphate synthetase, conserved site   GO:0004749 ribose phosphate diphosphokinase activity
Phosphoribosyl pyrophosphate synthetase, conserved site   GO:0009156 ribonucleoside monophosphate biosynthetic process
Phosphoribosyl pyrophosphate synthetase, conserved site   GO:0044249 cellular biosynthetic process

0 Parent Features

21 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076145 Q9VT33 Drosophila melanogaster
FBpp0076144 Q9VT32 Drosophila melanogaster
FBpp0302782 M9PEY1 Drosophila melanogaster
FBpp0302783 M9PHW7 Drosophila melanogaster
FBpp0305989 M9PEP5 Drosophila melanogaster
FBpp0305990 M9PF46 Drosophila melanogaster
FBpp0287140 Q29D45 Drosophila pseudoobscura
FBpp0161294 B4KVU8 Drosophila mojavensis
FBpp0227764 B4LHQ6 Drosophila virilis
A8XP61_CAEBR A8XP61 Caenorhabditis briggsae
H2WDI6_CAEJA H2WDI6 Caenorhabditis japonica
K7HES1_CAEJA K7HES1 Caenorhabditis japonica
G0N5K4_CAEBE G0N5K4 Caenorhabditis brenneri
Q95QB6_CAEEL Q95QB6 Caenorhabditis elegans
Q6AHR3_CAEEL Q6AHR3 Caenorhabditis elegans
Q9BI73_CAEEL Q9BI73 Caenorhabditis elegans
Q21994_CAEEL Q21994 Caenorhabditis elegans
F0JAG1_DROME F0JAG1 Drosophila melanogaster
B4PED9_DROYA B4PED9 Drosophila yakuba
E3MC52_CAERE E3MC52 Caenorhabditis remanei
E3LSY0_CAERE E3LSY0 Caenorhabditis remanei