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Protein Domain : IPR001345

Name  Phosphoglycerate/bisphosphoglycerate mutase, active site Short Name  PG/BPGM_mutase_AS
Type  Active_site Description  Phosphoglycerate mutase () (PGAM) and bisphosphoglycerate mutase () (BPGM) are structurally related enzymes that catalyse reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate [, , ]. Both enzymes can catalyse three different reactions with different specificities, the isomerization of 2-phosphoglycerate (2-PGA) to 3-phosphoglycerate (3-PGA) with 2,3-diphosphoglycerate (2,3-DPG) as the primer of the reaction, the synthesis of 2,3-DPG from 1,3-DPG with 3-PGA as a primer and the degradation of 2,3-DPG to 3-PGA (phosphatase activity).In mammals, PGAM is a dimeric protein with two isoforms, the M (muscle) and B (brain) forms. In yeast, PGAM is a tetrameric protein.BPGM is a dimeric protein and is found mainly in erythrocytes where it plays a major role in regulating haemoglobin oxygen affinity as a consequence of controlling 2,3-DPG concentration. The catalytic mechanism of both PGAM and BPGM involves the formation of a phosphohistidine intermediate [].A number of other proteins including, the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase []that catalyses both the synthesis and the degradation of fructose-2,6-bisphosphate and bacterial alpha-ribazole-5'-phosphate phosphatase, which is involved in cobalamin biosynthesis, belong to this family [].This entry contains the active site phosphohistidine residue.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00175 PROSITE IPR001345

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR005952 Phosphoglycerate mutase 1 Phosphogly_mut1 Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphoglycerate/bisphosphoglycerate mutase, active site   GO:0003824 catalytic activity
Phosphoglycerate/bisphosphoglycerate mutase, active site   GO:0008152 metabolic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphoglycerate/bisphosphoglycerate mutase, active site   GO:0003824 catalytic activity
Phosphoglycerate/bisphosphoglycerate mutase, active site   GO:0008152 metabolic process

0 Parent Features

41 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074487 Q0KHQ6 Drosophila melanogaster
FBpp0074486 Q9VWH7 Drosophila melanogaster
FBpp0099919 Q9VAN7 Drosophila melanogaster
FBpp0083616 Q8T8W6 Drosophila melanogaster
FBpp0083617 Q86BN5 Drosophila melanogaster
FBpp0083618 Q86BN6 Drosophila melanogaster
FBpp0082089 Q9VGB6 Drosophila melanogaster
FBpp0283608 Q29AB2 Drosophila pseudoobscura
FBpp0272859 Q29IW2 Drosophila pseudoobscura
FBpp0281457 Q295R2 Drosophila pseudoobscura
FBpp0282058 Q298T2 Drosophila pseudoobscura
FBpp0300253 I5ANV0 Drosophila pseudoobscura
FBpp0159497 B4KDY1 Drosophila mojavensis
FBpp0165308 B4L6W6 Drosophila mojavensis
FBpp0171598 B4K5D6 Drosophila mojavensis
FBpp0172409 B4KAZ1 Drosophila mojavensis
FBpp0225504 B4M5B8 Drosophila virilis
FBpp0228925 B4MBT4 Drosophila virilis
FBpp0230157 B4MA41 Drosophila virilis
FBpp0238831 B4LXT6 Drosophila virilis
FBpp0255305 B4PLP1 Drosophila yakuba
FBpp0260856 B4PZH7 Drosophila yakuba
FBpp0269548 B4PNP4 Drosophila yakuba
A8XBW5_CAEBR A8XBW5 Caenorhabditis briggsae
A8X920_CAEBR A8X920 Caenorhabditis briggsae
H2W661_CAEJA H2W661 Caenorhabditis japonica
H2W0B4_CAEJA H2W0B4 Caenorhabditis japonica
H2VI25_CAEJA H2VI25 Caenorhabditis japonica
G0NXJ7_CAEBE G0NXJ7 Caenorhabditis brenneri
G0NVZ7_CAEBE G0NVZ7 Caenorhabditis brenneri