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Protein Domain : IPR012151

Name  Protein-tyrosine phosphatase, non-receptor type-3, -4 Short Name  Tyr_Pase_non-rcpt_typ-3/4
Type  Family Description  Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [, ]. The PTP superfamily can be divided into four subfamilies []:(1) pTyr-specific phosphatases(2) dual specificity phosphatases (dTyr and dSer/dThr)(3) Cdc25 phosphatases (dTyr and/or dThr)(4) LMW (low molecular weight) phosphatasesBased on their cellular localisation, PTPases are also classified as:Receptor-like, which are transmembrane receptors that contain PTPase domains []Non-receptor (intracellular) PTPases []All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif []. Functional diversity between PTPases is endowed by regulatory domains and subunits. This entry represents a protein-tyrosine phosphatase, non-receptor types 3 and 4.

Publication Counts Displayer

0 Child Features

12 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR019748 FERM central domain FERM_central Domain
IPR000299 FERM domain FERM_domain Domain
IPR018979 FERM, N-terminal FERM_N Domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase Tyr/Dual-sp_Pase Domain
IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type Tyr_Pase_rcpt/non-rcpt Domain
IPR001478 PDZ domain PDZ Domain
IPR016130 Protein-tyrosine phosphatase, active site Tyr_Pase_AS Active_site
IPR014847 FERM adjacent (FA) FERM-adjacent Domain
IPR019747 FERM conserved site FERM_CS Conserved_site
IPR018980 FERM, C-terminal PH-like domain FERM_PH-like_C Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF000927 PIRSF IPR012151

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein-tyrosine phosphatase, non-receptor type-3, -4   GO:0004725 protein tyrosine phosphatase activity
Protein-tyrosine phosphatase, non-receptor type-3, -4   GO:0008092 cytoskeletal protein binding
Protein-tyrosine phosphatase, non-receptor type-3, -4   GO:0006470 protein dephosphorylation

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein-tyrosine phosphatase, non-receptor type-3, -4   GO:0004725 protein tyrosine phosphatase activity
Protein-tyrosine phosphatase, non-receptor type-3, -4   GO:0008092 cytoskeletal protein binding
Protein-tyrosine phosphatase, non-receptor type-3, -4   GO:0006470 protein dephosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR019750 Band 4.1 family Band_41_fam Family

13 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0297515 Q9W0R3 Drosophila melanogaster
FBpp0286684 Q29ET4 Drosophila pseudoobscura
FBpp0165954 B4L8Y1 Drosophila mojavensis
FBpp0226901 B4LCU6 Drosophila virilis
FBpp0266092 B4PC58 Drosophila yakuba
A8X9K5_CAEBR A8X9K5 Caenorhabditis briggsae
G0N5R3_CAEBE G0N5R3 Caenorhabditis brenneri
PTP1_CAEEL P28191 Caenorhabditis elegans
PTP1_CAEEL-3 P28191-3 Caenorhabditis elegans
PTP1_CAEEL-2 P28191-2 Caenorhabditis elegans
Q8IRJ0_DROME Q8IRJ0 Drosophila melanogaster
Q8WSF2_DROME Q8WSF2 Drosophila melanogaster
E3LT93_CAERE E3LT93 Caenorhabditis remanei