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Protein Domain : IPR019750

Name  Band 4.1 family Short Name  Band_41_fam
Type  Family Description  A number of cytoskeletal-associated proteins that associate with variousproteins at the interface between the plasma membrane and the cytoskeletoncontain a conserved N-terminal domain of about 150 residues [, , ]. Proteinsthat contain such a domain include: band 4.1, which links the spectrin-actinerythrocyte cytoskeleton to the plasma membrane; ezrin, a component of theundercoat of the microvilli plasma membrane; moesin, which is thought to beinvolved in binding major cytoskeletal structures to the plasma membrane;radixin, which appears to play a crucial role in binding the barbed end ofactin filaments to the plasma membrane in the undercoat of the cell-to-celladherens junction; talin, which binds to vinculin and with lesser affinityto integrins; filopodin, a slime mold protein that binds actin and isinvolved in the control of cell motility and chemotaxis; merlin, defects inwhich cause type 2 neurofibromatosis; protein NBL4; protein tyrosine phosphatases PTPN3, PTPN4, PTPN14, PTP-D1, PTP-RL10 and PTP2E; and C.elegansprotein phosphatase ptp-1.Ezrin, moesin and radixin are closely related, but other proteins containingthe domain share no other regions of similarity. In band 4.1, the domain plays a role in interactions with glycophorin, an integral membrane protein.

Publication Counts Displayer

4 Child Features

DB identifier Name Short Name Type
IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4 Tyr_Pase_non-rcpt_typ-3/4 Family
IPR000798 Ezrin/radixin/moesin like Ez/rad/moesin_like Family
IPR014392 Protein-tyrosine phosphatase, non-receptor type-14, -21 Tyr_Pase_non-rcpt_typ-14/21 Family
IPR012153 Protein-tyrosine phosphatase, non-receptor type-13 Tyr_Pase_non-rcpt_typ-13 Family

5 Contains

DB identifier Name Short Name Type
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle FERM/acyl-CoA-bd_prot_3-hlx Domain
IPR019748 FERM central domain FERM_central Domain
IPR018979 FERM, N-terminal FERM_N Domain
IPR019747 FERM conserved site FERM_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR00935 PRINTS IPR019750

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

126 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0082261 Q9VFU8 Drosophila melanogaster
FBpp0089236 P46150 Drosophila melanogaster
FBpp0078914 Q9V3V3 Drosophila melanogaster
FBpp0074523 Q24564 Drosophila melanogaster
FBpp0079589 Q9VKY7 Drosophila melanogaster
FBpp0085697 Q9V8R9 Drosophila melanogaster
FBpp0290494 H5V8A7 Drosophila melanogaster
FBpp0303991 M9PHG2 Drosophila melanogaster
FBpp0288485 A8JPC8 Drosophila melanogaster
FBpp0112924 A0T1Z5 Drosophila melanogaster
FBpp0112923 A0T1Z4 Drosophila melanogaster
FBpp0112925 B7Z0J2 Drosophila melanogaster
FBpp0307779 Q9VN68 Drosophila melanogaster
FBpp0307778 Q2M1E6 Drosophila melanogaster
FBpp0297515 Q9W0R3 Drosophila melanogaster
FBpp0300693 B5DY71 Drosophila pseudoobscura
FBpp0309093 Q28Z97 Drosophila pseudoobscura
FBpp0309094 N6WBW7 Drosophila pseudoobscura
FBpp0285901 Q29CW6 Drosophila pseudoobscura
FBpp0308184 N6VF07 Drosophila pseudoobscura
FBpp0308185 N6V854 Drosophila pseudoobscura
FBpp0298812 I5AP30 Drosophila pseudoobscura
FBpp0281848 Q297Q7 Drosophila pseudoobscura
FBpp0298810 I5AP28 Drosophila pseudoobscura
FBpp0298811 I5AP29 Drosophila pseudoobscura
FBpp0283339 B5DYS4 Drosophila pseudoobscura
FBpp0284534 Q29HY4 Drosophila pseudoobscura
FBpp0285844 Q29JN5 Drosophila pseudoobscura
FBpp0286684 Q29ET4 Drosophila pseudoobscura
FBpp0160236 B4L7Z7 Drosophila mojavensis