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Protein Domain : IPR019559

Name  Cullin protein, neddylation domain Short Name  Cullin_neddylation_domain
Type  Domain Description  This is the neddylation site of cullin proteins, which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae(Baker's yeast), and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue [].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR016157 Cullin, conserved site Cullin_CS Conserved_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF10557 PFAM IPR019559
SM00884 SMART IPR019559

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Cullin protein, neddylation domain   GO:0031625 ubiquitin protein ligase binding
Cullin protein, neddylation domain   GO:0006511 ubiquitin-dependent protein catabolic process
Cullin protein, neddylation domain   GO:0031461 cullin-RING ubiquitin ligase complex

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Cullin protein, neddylation domain   GO:0031625 ubiquitin protein ligase binding
Cullin protein, neddylation domain   GO:0006511 ubiquitin-dependent protein catabolic process
Cullin protein, neddylation domain   GO:0031461 cullin-RING ubiquitin ligase complex

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

70 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087921 Q24311 Drosophila melanogaster
FBpp0075633 Q9VU33 Drosophila melanogaster
FBpp0291367 Q9V475 Drosophila melanogaster
FBpp0085255 Q9V9R2 Drosophila melanogaster
FBpp0291369 Q8IP45 Drosophila melanogaster
FBpp0290569 Q5BI50 Drosophila melanogaster
FBpp0084786 Q9VAQ0 Drosophila melanogaster
FBpp0274492 Q2M0C4 Drosophila pseudoobscura
FBpp0277897 Q28ZW7 Drosophila pseudoobscura
FBpp0279434 Q29P05 Drosophila pseudoobscura
FBpp0283889 Q299A0 Drosophila pseudoobscura
FBpp0287799 Q29KT9 Drosophila pseudoobscura
FBpp0307544 Q28YB0 Drosophila pseudoobscura
FBpp0166659 B4KF20 Drosophila mojavensis
FBpp0169003 B4KQ35 Drosophila mojavensis
FBpp0169492 B4KNX2 Drosophila mojavensis
FBpp0171943 B4KLG3 Drosophila mojavensis
FBpp0172627 B4K7W9 Drosophila mojavensis
FBpp0225033 B4M5P4 Drosophila virilis
FBpp0228647 B4LUQ0 Drosophila virilis
FBpp0232167 B4ME02 Drosophila virilis
FBpp0234645 B4LJM1 Drosophila virilis
FBpp0237705 B4LV44 Drosophila virilis
FBpp0255490 B4PQ77 Drosophila yakuba
FBpp0257934 B4P6G6 Drosophila yakuba
FBpp0264166 B4P251 Drosophila yakuba
FBpp0264420 B4NYC8 Drosophila yakuba
FBpp0265093 B4PHA8 Drosophila yakuba
FBpp0268333 B4P290 Drosophila yakuba
A8XVU3_CAEBR A8XVU3 Caenorhabditis briggsae