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Protein Domain : IPR000630

Name  Ribosomal protein S8 Short Name  Ribosomal_S8
Type  Family Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].Ribosomal protein S8 is one of the proteins from the small ribosomal subunit. In Escherichia coli, S8 is known to binddirectly to 16S ribosomal RNA. It belongs to a family of ribosomal proteins which, on the basis of sequencesimilarities [], groups eubacterial, algal and plant chloroplast, cyanelle, archaebacterial andMarchantia polymorphamitochondrial S8; mammalian and plant S15A; and yeast S22 (S24) ribosomal proteins.

Publication Counts Displayer

0 Child Features

0 Contains

6 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR11758 PANTHER IPR000630
PF00410 PFAM IPR000630
PS00053 PROSITE IPR000630
SSF56047 SSF IPR000630
MF_01302_A HAMAP IPR000630
MF_01302_B HAMAP IPR000630

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein S8   GO:0003735 structural constituent of ribosome
Ribosomal protein S8   GO:0006412 translation
Ribosomal protein S8   GO:0005840 ribosome

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein S8   GO:0003735 structural constituent of ribosome
Ribosomal protein S8   GO:0006412 translation
Ribosomal protein S8   GO:0005840 ribosome

0 Parent Features

12 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087321 Q7KR04 Drosophila melanogaster
FBpp0073626 P48149 Drosophila melanogaster
FBpp0273499 Q29IR2 Drosophila pseudoobscura
A8XDU2_CAEBR A8XDU2 Caenorhabditis briggsae
B4MA18_DROVI B4MA18 Drosophila virilis
H2WR56_CAEJA H2WR56 Caenorhabditis japonica
G0NBR6_CAEBE G0NBR6 Caenorhabditis brenneri
A8WIR1_CAEEL A8WIR1 Caenorhabditis elegans
O17218_CAEEL O17218 Caenorhabditis elegans
RS15A_DROYA Q6XIM8 Drosophila yakuba
E3MNP9_CAERE E3MNP9 Caenorhabditis remanei
B4L6U3_DROMO B4L6U3 Drosophila mojavensis