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Protein Domain : IPR023174

Name  3'5'-cyclic nucleotide phosphodiesterase, conserved site Short Name  PDEase_CS
Type  Conserved_site Description  The cyclic nucleotide phosphodiesterases (PDE) comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They are divided into 11 families. They regulate the localisation, duration and amplitude of cyclic nucleotide signalling within subcellular domains. PDEs are therefore important for signal transduction.PDE enzymes are often targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties. Inhibitors include: Roflumilast for chronic obstructive pulmonary disease and asthma [], Sildenafil for erectile dysfunction []and Cilostazol for peripheral arterial occlusive disease [], amongst others.Retinal 3',5'-cGMP phosphodiesterase is located in photoreceptor outer segments: it is light activated, playing a pivotal role in signal transduction. In rod cells, PDE is oligomeric, comprising an alpha-, a beta- and 2 gamma-subunits, while in cones, PDE is a homodimer of alpha chains, which are associated with several smaller subunits. Both rod and cone PDEs catalyse the hydrolysis of cAMP or cGMP to the corresponding nucleoside 5' monophosphates, both enzymes also bindingcGMP with high affinity. The cGMP-binding sites are located in theN-terminal half of the protein sequence, while the catalytic core resides in the C-terminal portion.3'5'-cyclic nucleotide phosphodiesterases (dbxref db='EC' id='3.1.4.17'/>) (PDEases) catalyze the hydrolysis of cAMP or cGMP to the corresponding nucleoside 5' monophosphates []. There are at least seven different subfamilies of PDEases []: Type 1, calmodulin/calcium-dependent PDEases. Type 2, cGMP-stimulated PDEases. Type 3, cGMP-inhibited PDEases. Type 4, cAMP-specific PDEases. Type 5, cGMP-specific PDEases. Type 6, rhodopsin-sensitive cGMP-specific PDEases. Type 7, High affinity cAMP-specific PDEases. All of these forms seem to share a conserved domain of about 270 residues. This entry has a signature pattern from a stretch of 12 residues that contains two conserved histidines.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00126 PROSITE IPR023174

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
3'5'-cyclic nucleotide phosphodiesterase, conserved site   GO:0008081 phosphoric diester hydrolase activity

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
3'5'-cyclic nucleotide phosphodiesterase, conserved site   GO:0008081 phosphoric diester hydrolase activity

0 Parent Features

98 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070495 Q9W4S9 Drosophila melanogaster
FBpp0070487 P12252 Drosophila melanogaster
FBpp0070494 M9PDN2 Drosophila melanogaster
FBpp0070497 Q8IRU4 Drosophila melanogaster
FBpp0070485 Q9W4T4 Drosophila melanogaster
FBpp0306255 B7YZV2 Drosophila melanogaster
FBpp0306258 M9PDA0 Drosophila melanogaster
FBpp0306257 B7YZV4 Drosophila melanogaster
FBpp0306259 B7YZV3 Drosophila melanogaster
FBpp0306252 M9NF02 Drosophila melanogaster
FBpp0306254 Q9VKE9 Drosophila melanogaster
FBpp0306256 B7YZV1 Drosophila melanogaster
FBpp0289559 Q9VFI9 Drosophila melanogaster
FBpp0111456 Q9VJ79 Drosophila melanogaster
FBpp0288910 Q9I7S6 Drosophila melanogaster
FBpp0292262 M9MRK1 Drosophila melanogaster
FBpp0292261 M9MSJ0 Drosophila melanogaster
FBpp0303421 Q9VYJ0 Drosophila melanogaster
FBpp0300350 Q298P4 Drosophila pseudoobscura
FBpp0279732 Q29LM0 Drosophila pseudoobscura
FBpp0272327 Q29FT2 Drosophila pseudoobscura
FBpp0280052 B5DHZ2 Drosophila pseudoobscura
FBpp0286902 B5DMB6 Drosophila pseudoobscura
FBpp0160283 B4L7R8 Drosophila mojavensis
FBpp0159885 B4K9L4 Drosophila mojavensis
FBpp0166907 B4KIV6 Drosophila mojavensis
FBpp0234246 B4LTJ1 Drosophila virilis
FBpp0229723 B4MCU3 Drosophila virilis
FBpp0231893 B4LQJ7 Drosophila virilis
FBpp0237436 B4LVU6 Drosophila virilis