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Protein Domain : IPR004182

Name  GRAM domain Short Name  GRAM
Type  Domain Description  The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. It is normally about 70 amino acids in length. It is thought to be an intracellular protein-binding or lipid-binding signalling domain, which has an important function in membrane-associated processes. The structure of the GRAM domain is similar to that found in PH domains []. Mutations in the GRAM domain of myotubularins cause a muscle disease, which suggests that the domain is essential for the full function of the enzyme []. Myotubularin-related proteins are a large subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids [].

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Source . Name

Subject . Primary Identifier
PF02893 PFAM IPR004182
SM00568 SMART IPR004182

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

80 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0271749 Q95SE8 Drosophila melanogaster
FBpp0304357 M9PFH0 Drosophila melanogaster
FBpp0304358 F0JAQ9 Drosophila melanogaster
FBpp0304356 Q9VU19 Drosophila melanogaster
FBpp0304355 M9PF27 Drosophila melanogaster
FBpp0082003 Q9VGH9 Drosophila melanogaster
FBpp0082004 Q7KSP6 Drosophila melanogaster
FBpp0078058 Q9VP46 Drosophila melanogaster
FBpp0078854 Q9VMI9 Drosophila melanogaster
FBpp0111550 A8DYU1 Drosophila melanogaster
FBpp0111553 A8DYU3 Drosophila melanogaster
FBpp0304682 R9PY34 Drosophila melanogaster
FBpp0297429 R9PY62 Drosophila melanogaster
FBpp0111551 A8DYU2 Drosophila melanogaster
FBpp0304182 M9PIF1 Drosophila melanogaster
FBpp0280651 B5DIJ6 Drosophila pseudoobscura
FBpp0274072 Q2LYX3 Drosophila pseudoobscura
FBpp0274000 B5DQB9 Drosophila pseudoobscura
FBpp0279219 Q29PM8 Drosophila pseudoobscura
FBpp0284675 Q294Z3 Drosophila pseudoobscura
FBpp0159518 B4KE12 Drosophila mojavensis
FBpp0160505 B4KGH4 Drosophila mojavensis
FBpp0160884 B4L0T6 Drosophila mojavensis
FBpp0162526 B4KWU9 Drosophila mojavensis
FBpp0170737 B4L5G3 Drosophila mojavensis
FBpp0224571 B4M4W2 Drosophila virilis
FBpp0224798 B4LTI4 Drosophila virilis
FBpp0225762 B4LBI9 Drosophila virilis
FBpp0226496 B4LH22 Drosophila virilis
FBpp0226891 B4LR85 Drosophila virilis