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Protein Domain : IPR005946

Name  Ribose-phosphate diphosphokinase Short Name  Rib-P_diPkinase
Type  Family Description  Ribose-phosphate diphosphokinase (RPPK), also known as phosphoribosyldiphosphate synthetase (), catalyses the transfer of an intact diphosphate (PP) group from ATP to ribose-5-phosphate (R-5-P), which results in the formation of AMP and 5-phospho-D-ribosyl--1-diphosphate (PRPP). PRPP is an essential precursor for purine and pyrimidine nucleotides, both in the de novo synthesis and in the salvage pathway, as well as in the synthesis of pyridine nucleotide coenzymes. The activity of PPPK is highly regulated. Besides competitive inhibition at the substrate binding sites, most RPPKs are regulated in an allosteric manner, in which ADP generally acts as the most potent inhibitor. In some systems, close homologues lacking enzymatic activity exist and perform regulatory functions.

Publication Counts Displayer

0 Child Features

2 Contains

DB identifier Name Short Name Type
IPR000836 Phosphoribosyltransferase domain PRibTrfase_dom Domain
IPR000842 Phosphoribosyl pyrophosphate synthetase, conserved site PRib_PP_synth_CS Conserved_site

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF14572 PFAM IPR005946
TIGR01251 TIGRFAMs IPR005946
MF_00583_A HAMAP IPR005946
MF_00583_B HAMAP IPR005946

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribose-phosphate diphosphokinase   GO:0000287 magnesium ion binding
Ribose-phosphate diphosphokinase   GO:0004749 ribose phosphate diphosphokinase activity
Ribose-phosphate diphosphokinase   GO:0009165 nucleotide biosynthetic process

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribose-phosphate diphosphokinase   GO:0000287 magnesium ion binding
Ribose-phosphate diphosphokinase   GO:0004749 ribose phosphate diphosphokinase activity
Ribose-phosphate diphosphokinase   GO:0009165 nucleotide biosynthetic process

0 Parent Features

40 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076145 Q9VT33 Drosophila melanogaster
FBpp0076144 Q9VT32 Drosophila melanogaster
FBpp0085035 Q9VA53 Drosophila melanogaster
FBpp0085037 Q8IMI0 Drosophila melanogaster
FBpp0085036 Q7KRU0 Drosophila melanogaster
FBpp0085038 Q961V3 Drosophila melanogaster
FBpp0302782 M9PEY1 Drosophila melanogaster
FBpp0302783 M9PHW7 Drosophila melanogaster
FBpp0305989 M9PEP5 Drosophila melanogaster
FBpp0305990 M9PF46 Drosophila melanogaster
FBpp0285339 B5DS53 Drosophila pseudoobscura
FBpp0287140 Q29D45 Drosophila pseudoobscura
FBpp0283085 B5DXB3 Drosophila pseudoobscura
FBpp0301933 I5AMV5 Drosophila pseudoobscura
FBpp0301934 I5AMV6 Drosophila pseudoobscura
FBpp0159859 B4K9I2 Drosophila mojavensis
FBpp0161294 B4KVU8 Drosophila mojavensis
FBpp0227764 B4LHQ6 Drosophila virilis
FBpp0237415 B4LVX8 Drosophila virilis
FBpp0268383 B4PMJ4 Drosophila yakuba
A8XRC1_CAEBR A8XRC1 Caenorhabditis briggsae
A8XP61_CAEBR A8XP61 Caenorhabditis briggsae
A8XR21_CAEBR A8XR21 Caenorhabditis briggsae
H2VXR6_CAEJA H2VXR6 Caenorhabditis japonica
H2WDI6_CAEJA H2WDI6 Caenorhabditis japonica
K7HES1_CAEJA K7HES1 Caenorhabditis japonica
G0MI46_CAEBE G0MI46 Caenorhabditis brenneri
G0N269_CAEBE G0N269 Caenorhabditis brenneri
G0N5K4_CAEBE G0N5K4 Caenorhabditis brenneri
Q95QB6_CAEEL Q95QB6 Caenorhabditis elegans