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Protein Domain : IPR001895

Name  Guanine-nucleotide dissociation stimulator CDC25 Short Name  RasGRF_CDC25
Type  Domain Description  Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP []. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP [, ]. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) (or also as guanine-nucleotide releasing (or exchange) factors (GRFs)). Proteins that act as GDS can be classified into at least two families, on the basis of sequence similarities, the CDC24 family (see ) and the CDC25 family.The size of the proteins of the CDC25 family range from 309 residues (LTE1) to 1596 residues (sos). The sequence similarity shared by all these proteins is limited to a region of about 250 amino acids generally located in their C-terminal section (currently the only exceptions are sos and ralGDS where this domain makes up the central part of the protein). This domain has been shown, in CDC25 an SCD25, to be essential for the activity of these proteins.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR019804 Ras guanine-nucleotide exchange factor, conserved site Ras_G-nucl-exch_fac_CS Conserved_site

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00617 PFAM IPR001895
PS50009 PROFILE IPR001895
SM00147 SMART IPR001895
G3DSA:1.10.840.10 GENE3D IPR001895

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR015758 Ral guanine nucleotide dissociation stimulator RalGDS Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Guanine-nucleotide dissociation stimulator CDC25   GO:0005085 guanyl-nucleotide exchange factor activity
Guanine-nucleotide dissociation stimulator CDC25   GO:0007264 small GTPase mediated signal transduction
Guanine-nucleotide dissociation stimulator CDC25   GO:0005622 intracellular

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Guanine-nucleotide dissociation stimulator CDC25   GO:0005085 guanyl-nucleotide exchange factor activity
Guanine-nucleotide dissociation stimulator CDC25   GO:0007264 small GTPase mediated signal transduction
Guanine-nucleotide dissociation stimulator CDC25   GO:0005622 intracellular

0 Parent Features

138 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0289316 B7Z026 Drosophila melanogaster
FBpp0289315 B7Z025 Drosophila melanogaster
FBpp0078879 Q9VMF3 Drosophila melanogaster
FBpp0078860 Q8T010 Drosophila melanogaster
FBpp0078859 Q9VMJ4 Drosophila melanogaster
FBpp0086177 Q0E949 Drosophila melanogaster
FBpp0086179 Q8MT78 Drosophila melanogaster
FBpp0080118 P26675 Drosophila melanogaster
FBpp0086095 A1ZAU6 Drosophila melanogaster
FBpp0075535 Q9U4U5 Drosophila melanogaster
FBpp0075536 Q86BI2 Drosophila melanogaster
FBpp0078182 Q7KTU3 Drosophila melanogaster
FBpp0111549 Q9VQM8 Drosophila melanogaster
FBpp0289070 B7Z132 Drosophila melanogaster
FBpp0289073 B7Z131 Drosophila melanogaster
FBpp0289753 O77086 Drosophila melanogaster
FBpp0289072 B7Z130 Drosophila melanogaster
FBpp0111548 Q7K3Z6 Drosophila melanogaster
FBpp0289071 B7Z129 Drosophila melanogaster
FBpp0303219 M9PCE9 Drosophila melanogaster
FBpp0306980 M9PJ95 Drosophila melanogaster
FBpp0306982 M9PGJ9 Drosophila melanogaster
FBpp0274406 Q2M017 Drosophila pseudoobscura
FBpp0274612 B5DQP9 Drosophila pseudoobscura
FBpp0272752 Q29IL8 Drosophila pseudoobscura
FBpp0277143 B5E1B7 Drosophila pseudoobscura
FBpp0277632 Q291F9 Drosophila pseudoobscura
FBpp0278166 Q28YW0 Drosophila pseudoobscura
FBpp0308215 N6WC08 Drosophila pseudoobscura
FBpp0279223 Q29PM3 Drosophila pseudoobscura