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Protein Domain : IPR023578

Name  Ras guanine nucleotide exchange factor, domain Short Name  Ras_GEF_dom
Type  Domain Description  Small GTPases of the Ras family alternate between 2 conformations induced by the binding of either GTP or GDP. Guanine nucleotide exchange factors (GEFs) induce the dissociation of GDP to allow association of the more abundant GTP. The Ras-like family of small GTPases includes, among others, Ras, Rap1, R-ras, and Ral. The family is characterised by similarities in the effector domain. The Ras GTPase Rap1 is activated rapidly in response to activation of a variety of receptors. Rap1 activation is mediated by several second messengers, including calcium, diacylglycerol, and cAMP. GEFs have been identified that mediate these effects. One such GEF is Epac, an exchange protein directly activated by cAMP, which represents a novel cAMP-induced, protein kinase A-independent pathway [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SSF48366 SSF IPR023578

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

141 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0289316 B7Z026 Drosophila melanogaster
FBpp0289315 B7Z025 Drosophila melanogaster
FBpp0078879 Q9VMF3 Drosophila melanogaster
FBpp0078860 Q8T010 Drosophila melanogaster
FBpp0078859 Q9VMJ4 Drosophila melanogaster
FBpp0086177 Q0E949 Drosophila melanogaster
FBpp0086179 Q8MT78 Drosophila melanogaster
FBpp0080118 P26675 Drosophila melanogaster
FBpp0086095 A1ZAU6 Drosophila melanogaster
FBpp0075535 Q9U4U5 Drosophila melanogaster
FBpp0075536 Q86BI2 Drosophila melanogaster
FBpp0078182 Q7KTU3 Drosophila melanogaster
FBpp0111549 Q9VQM8 Drosophila melanogaster
FBpp0289070 B7Z132 Drosophila melanogaster
FBpp0289073 B7Z131 Drosophila melanogaster
FBpp0289753 O77086 Drosophila melanogaster
FBpp0289072 B7Z130 Drosophila melanogaster
FBpp0111548 Q7K3Z6 Drosophila melanogaster
FBpp0289071 B7Z129 Drosophila melanogaster
FBpp0303219 M9PCE9 Drosophila melanogaster
FBpp0306980 M9PJ95 Drosophila melanogaster
FBpp0306982 M9PGJ9 Drosophila melanogaster
FBpp0274406 Q2M017 Drosophila pseudoobscura
FBpp0274612 B5DQP9 Drosophila pseudoobscura
FBpp0272752 Q29IL8 Drosophila pseudoobscura
FBpp0277143 B5E1B7 Drosophila pseudoobscura
FBpp0277632 Q291F9 Drosophila pseudoobscura
FBpp0278166 Q28YW0 Drosophila pseudoobscura
FBpp0308215 N6WC08 Drosophila pseudoobscura
FBpp0279223 Q29PM3 Drosophila pseudoobscura