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Protein Domain : IPR000651

Name  Ras-like guanine nucleotide exchange factor, N-terminal Short Name  Ras-like_Gua-exchang_fac_N
Type  Domain Description  The crystal structure of the guanine nucleotide exchange factor (GEF) region of human Sos1 complexes with Ras hasbeen solved []. The structure consists of two distinct alpha helical structural domains: the N-terminal domain which seems to have a purely structural role and the C-terminal domain which is sufficient for catalyticactivity and contains all residues that interact with Ras. A main feature ofthe catalytic domain is the protrusion of a helical hairpin important for thenucleotide-exchange mechanism. The N-terminal domain is likely to be importantfor the stability and correct placement of the hairpin structure.This entry represents a domain found in several GEF for Ras-like small GTPases which lies N-terminal to the RasGef (Cdc25-like) domain.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00618 PFAM IPR000651
PS50212 PROFILE IPR000651
SM00229 SMART IPR000651

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR015758 Ral guanine nucleotide dissociation stimulator RalGDS Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ras-like guanine nucleotide exchange factor, N-terminal   GO:0005085 guanyl-nucleotide exchange factor activity
Ras-like guanine nucleotide exchange factor, N-terminal   GO:0051056 regulation of small GTPase mediated signal transduction
Ras-like guanine nucleotide exchange factor, N-terminal   GO:0005622 intracellular

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ras-like guanine nucleotide exchange factor, N-terminal   GO:0005085 guanyl-nucleotide exchange factor activity
Ras-like guanine nucleotide exchange factor, N-terminal   GO:0051056 regulation of small GTPase mediated signal transduction
Ras-like guanine nucleotide exchange factor, N-terminal   GO:0005622 intracellular

0 Parent Features

111 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0289316 B7Z026 Drosophila melanogaster
FBpp0289315 B7Z025 Drosophila melanogaster
FBpp0078879 Q9VMF3 Drosophila melanogaster
FBpp0080118 P26675 Drosophila melanogaster
FBpp0086095 A1ZAU6 Drosophila melanogaster
FBpp0075535 Q9U4U5 Drosophila melanogaster
FBpp0075536 Q86BI2 Drosophila melanogaster
FBpp0078182 Q7KTU3 Drosophila melanogaster
FBpp0111549 Q9VQM8 Drosophila melanogaster
FBpp0289070 B7Z132 Drosophila melanogaster
FBpp0289073 B7Z131 Drosophila melanogaster
FBpp0289753 O77086 Drosophila melanogaster
FBpp0289072 B7Z130 Drosophila melanogaster
FBpp0111548 Q7K3Z6 Drosophila melanogaster
FBpp0289071 B7Z129 Drosophila melanogaster
FBpp0303219 M9PCE9 Drosophila melanogaster
FBpp0306980 M9PJ95 Drosophila melanogaster
FBpp0306982 M9PGJ9 Drosophila melanogaster
FBpp0274406 Q2M017 Drosophila pseudoobscura
FBpp0274612 B5DQP9 Drosophila pseudoobscura
FBpp0272752 Q29IL8 Drosophila pseudoobscura
FBpp0277143 B5E1B7 Drosophila pseudoobscura
FBpp0277632 Q291F9 Drosophila pseudoobscura
FBpp0285623 Q29JN4 Drosophila pseudoobscura
FBpp0287317 B5DK13 Drosophila pseudoobscura
FBpp0287726 Q29L35 Drosophila pseudoobscura
FBpp0160737 B4KFY7 Drosophila mojavensis
FBpp0162642 B4KYJ5 Drosophila mojavensis
FBpp0162673 B4KYV6 Drosophila mojavensis
FBpp0167284 B4KG26 Drosophila mojavensis