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Protein Domain : IPR013201

Name  Proteinase inhibitor I29, cathepsin propeptide Short Name  Prot_inhib_I29
Type  Domain Description  This entry represents a peptidase inhibitor domain, which belongs to MEROPS peptidase inhibitor family I29. The domain is also found at the N terminus of a variety of peptidase precursors that belong to MEROPS peptidase subfamily C1A; these include cathepsin L, papain, and procaricain () []. It forms an alpha-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by proteolytic cleavage results in activation of the enzyme. This domain is also found, in one or more copies, in a variety of cysteine peptidase inhibitors such as salarin [].

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF08246 PFAM IPR013201
SM00848 SMART IPR013201

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

3 Found In

DB identifier Name Short Name Type
IPR013128 Peptidase C1A Peptidase_C1A Family
IPR015645 Peptidase C1A, placentally-expressed cathepsin Pept_C1A_placental-cathepsin Family
IPR015644 Peptidase C1A, cathepsin K Peptidase_C1A_cathepsin-K Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

135 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086719 Q95029 Drosophila melanogaster
FBpp0086763 Q7K0S6 Drosophila melanogaster
FBpp0079644 Q9VKY4 Drosophila melanogaster
FBpp0075508 Q9V3U6 Drosophila melanogaster
FBpp0085735 A1ZBK7 Drosophila melanogaster
FBpp0078272 Q9VNK6 Drosophila melanogaster
FBpp0086772 Q7JYA0 Drosophila melanogaster
FBpp0086764 A1Z9I0 Drosophila melanogaster
FBpp0078465 Q9VN93 Drosophila melanogaster
FBpp0078464 H5V8F3 Drosophila melanogaster
FBpp0086091 A1ZAU4 Drosophila melanogaster
FBpp0086090 Q7K5N8 Drosophila melanogaster
FBpp0277438 Q292E5 Drosophila pseudoobscura
FBpp0275168 Q2M011 Drosophila pseudoobscura
FBpp0274400 B5DPR9 Drosophila pseudoobscura
FBpp0274603 B5DQQ6 Drosophila pseudoobscura
FBpp0277631 Q291G0 Drosophila pseudoobscura
FBpp0278438 Q28XY3 Drosophila pseudoobscura
FBpp0300603 I5APD1 Drosophila pseudoobscura
FBpp0284455 B5DY59 Drosophila pseudoobscura
FBpp0276105 B5E0E3 Drosophila pseudoobscura
FBpp0278526 Q28XK9 Drosophila pseudoobscura
FBpp0276104 B5E0E4 Drosophila pseudoobscura
FBpp0306123 N6VFP6 Drosophila pseudoobscura
FBpp0160081 B4LAU1 Drosophila mojavensis
FBpp0159433 B4KCM1 Drosophila mojavensis
FBpp0160847 B4L168 Drosophila mojavensis
FBpp0162893 B4L162 Drosophila mojavensis
FBpp0163320 B4L7D4 Drosophila mojavensis
FBpp0167675 B4KT94 Drosophila mojavensis