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Protein Domain : IPR025660

Name  Cysteine peptidase, histidine active site Short Name  Pept_his_AS
Type  Active_site Description  Thiol (cysteine) proteases (EC 3.4.22.-) []are a family of proteolytic enzymes which contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is facilitated by a nearby histidine side chain; an asparagine completes the essential catalytic triad.Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad (cysteine-histidene) or triad [].Modification of the catalytic triad, especially of its first amino acid (cysteine), has been postulated as a suitable target for a chemical modulation of enzyme function. This is the case for silicateins, where the cysteine residue has been replaced by a serine []. Silicateins represent a group of enzymes possessing bi-functional activity; in addition to the silica-condensing activity, they possess a proteolytic (cathepsin-like) activity [].The sequences around the three active site residues are well conserved. This entry represents the histidine active site. The catalytic triad consists of this entry, and . This catalytic triad detects mainly proteases of the C1 family, including papain and several cathepsins.

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0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS00639 PROSITE IPR025660

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

148 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086719 Q95029 Drosophila melanogaster
FBpp0086763 Q7K0S6 Drosophila melanogaster
FBpp0079644 Q9VKY4 Drosophila melanogaster
FBpp0075508 Q9V3U6 Drosophila melanogaster
FBpp0078272 Q9VNK6 Drosophila melanogaster
FBpp0078465 Q9VN93 Drosophila melanogaster
FBpp0078464 H5V8F3 Drosophila melanogaster
FBpp0073669 Q9VY87 Drosophila melanogaster
FBpp0071697 Q7JWQ7 Drosophila melanogaster
FBpp0278474 Q28XS2 Drosophila pseudoobscura
FBpp0275168 Q2M011 Drosophila pseudoobscura
FBpp0274400 B5DPR9 Drosophila pseudoobscura
FBpp0274603 B5DQQ6 Drosophila pseudoobscura
FBpp0284278 Q29HU8 Drosophila pseudoobscura
FBpp0300603 I5APD1 Drosophila pseudoobscura
FBpp0284455 B5DY59 Drosophila pseudoobscura
FBpp0278526 Q28XK9 Drosophila pseudoobscura
FBpp0276104 B5E0E4 Drosophila pseudoobscura
FBpp0306123 N6VFP6 Drosophila pseudoobscura
FBpp0159433 B4KCM1 Drosophila mojavensis
FBpp0160847 B4L168 Drosophila mojavensis
FBpp0162893 B4L162 Drosophila mojavensis
FBpp0163320 B4L7D4 Drosophila mojavensis
FBpp0164720 B4L388 Drosophila mojavensis
FBpp0167804 B4KQX9 Drosophila mojavensis
FBpp0167857 B4KPW6 Drosophila mojavensis
FBpp0168256 B4KRY5 Drosophila mojavensis
FBpp0170067 B4KNQ5 Drosophila mojavensis
FBpp0170422 B4KTB9 Drosophila mojavensis
FBpp0233679 B4M3R5 Drosophila virilis