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Protein Domain : IPR000169

Name  Cysteine peptidase, cysteine active site Short Name  Pept_cys_AS
Type  Active_site Description  Thiol (cysteine) proteases (EC 3.4.22.-) []are a family of proteolytic enzymes which contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is facilitated by a nearby histidine side chain; an asparagine completes the essential catalytic triad.Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad (cysteine-histidene) or triad [].Modification of the catalytic triad, especially of its first amino acid (cysteine), has been postulated as a suitable target for a chemical modulation of enzyme function. This is the case for silicateins, where the cysteine residue has been replaced by a serine []. Silicateins represent a group of enzymes possessing bi-functional activity; in addition to the silica-condensing activity, they possess a proteolytic (cathepsin-like) activity [].The sequences around the three active site residues are well conserved. This entry represents the cysteine active site. The catalytic triad consists of this entry, and . This catalytic triad detects mainly proteases of the C1 family, including papain and several cathepsins.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS00139 PROSITE IPR000169

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

6 Found In

DB identifier Name Short Name Type
IPR013128 Peptidase C1A Peptidase_C1A Family
IPR022684 Peptidase C2, calpain family Calpain_cysteine_protease Family
IPR001300 Peptidase C2, calpain, catalytic domain Peptidase_C2_calpain_cat Domain
IPR015643 Peptidase C1A, cathepsin B Peptidase_C1A_cathepsin-B Family
IPR015645 Peptidase C1A, placentally-expressed cathepsin Pept_C1A_placental-cathepsin Family
IPR015644 Peptidase C1A, cathepsin K Peptidase_C1A_cathepsin-K Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

205 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086719 Q95029 Drosophila melanogaster
FBpp0075508 Q9V3U6 Drosophila melanogaster
FBpp0085714 Q11002 Drosophila melanogaster
FBpp0076072 Q9VT65 Drosophila melanogaster
FBpp0088620 P27398 Drosophila melanogaster
FBpp0088619 F3YDK6 Drosophila melanogaster
FBpp0290798 E1JJ98 Drosophila melanogaster
FBpp0071144 Q9W3F6 Drosophila melanogaster
FBpp0078465 Q9VN93 Drosophila melanogaster
FBpp0078464 H5V8F3 Drosophila melanogaster
FBpp0086091 A1ZAU4 Drosophila melanogaster
FBpp0086090 Q7K5N8 Drosophila melanogaster
FBpp0073669 Q9VY87 Drosophila melanogaster
FBpp0111875 A8JV22 Drosophila melanogaster
FBpp0275168 Q2M011 Drosophila pseudoobscura
FBpp0274319 Q2LZQ6 Drosophila pseudoobscura
FBpp0277097 B5E1I7 Drosophila pseudoobscura
FBpp0277631 Q291G0 Drosophila pseudoobscura
FBpp0284278 Q29HU8 Drosophila pseudoobscura
FBpp0300603 I5APD1 Drosophila pseudoobscura
FBpp0284455 B5DY59 Drosophila pseudoobscura
FBpp0287347 Q29HJ1 Drosophila pseudoobscura
FBpp0278526 Q28XK9 Drosophila pseudoobscura
FBpp0306123 N6VFP6 Drosophila pseudoobscura
FBpp0161531 B4L097 Drosophila mojavensis
FBpp0159433 B4KCM1 Drosophila mojavensis
FBpp0160847 B4L168 Drosophila mojavensis
FBpp0162893 B4L162 Drosophila mojavensis
FBpp0164720 B4L388 Drosophila mojavensis
FBpp0164982 B4L4I0 Drosophila mojavensis