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Protein Domain : IPR006020

Name  PTB/PI domain Short Name  PTB/PI_dom
Type  Domain Description  Proteins encoding phosphotyrosine binding (PTB) domains function as adaptorsor scaffolds to organise the signaling complexes involved in wide-rangingphysiological processes including neural development, immunity, tissuehomeostasis and cell growth. Due to structural differences, PTB domains aredivided into three groups represented by phosphotyrosine-dependent IRS-like, phosphotyrosine-dependent Shc-like, and phosphotyrosine-independent Dab-like PTBs. The last two PTBs have been named asphosphotyrosine interaction domain (PID or PI domain). PID domain has anaverage length of about 160 amino acids [].The Shc-like PID specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found inmany tyrosine-phosphorylated proteins including growth factor receptors. Onthe other hand the Dab-like PID domain binds to non-phosphorylated tyrosineresidue or even a phenylalanine at the same position []. Most of the ligands for Shc-like PID domains are RTK or cytokine, whereas phosphotyrosineindependent Dab-like PID domains seems to mediate other types of signalingpathways, like endocytosis/processing or exocytosis. This domain binds bothpeptides and headgroups of phosphatidylinositides, utilising two distinctbinding motifs to mediate spatial organisation and localisation within cells[, , , ].The 3D structure of PID domain has been solved []. It shares a folding pattern, commonly referred to as the PH-domain "superfold". The core "superfold" consists of seven antiparallel beta strands forming two orthogonal beta sheets. This beta sandwich is capped at the C terminus by an alpha helix. It contains a peptide binding pocket (formed by the beta strand 5 and C-terminal alpha helix) and a highly basic phospholipid binding "crown"(largely composed of residues from loop regions near the N terminus). Both Shcand Dab1 have two additional alpha helices, one of which is located at the Nterminus and the other between beta 1 and beta 2 strands.

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR006019 Phosphotyrosine interaction domain, Shc-like PID_Shc-like Domain

0 Contains

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00640 PFAM IPR006020
PF14719 PFAM IPR006020
PS01179 PROFILE IPR006020
SM00462 SMART IPR006020

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR016698 Numb/numb-like Numb/numb-like Family
IPR019517 Integrin binding protein, ICAP-1 Integrin-bd_ICAP-1 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
PTB/PI domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
PTB/PI domain   GO:0005515 protein binding

1 Parent Features

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain

207 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081554 Q86BA6 Drosophila melanogaster
FBpp0081553 Q9VHA6 Drosophila melanogaster
FBpp0075077 P98081 Drosophila melanogaster
FBpp0084091 Q9VC09 Drosophila melanogaster
FBpp0087632 Q7JUY7 Drosophila melanogaster
FBpp0083666 Q9VCX1 Drosophila melanogaster
FBpp0079420 P16554 Drosophila melanogaster
FBpp0074225 Q9VX41 Drosophila melanogaster
FBpp0072523 Q9W0K0 Drosophila melanogaster
FBpp0076186 Q9V3C8 Drosophila melanogaster
FBpp0309789 M9PGU7 Drosophila melanogaster
FBpp0072949 Q9VZR5 Drosophila melanogaster
FBpp0291851 M9MRS2 Drosophila melanogaster
FBpp0071422 Q9W2S5 Drosophila melanogaster
FBpp0290307 Q9VCM6 Drosophila melanogaster
FBpp0309484 M9PF12 Drosophila melanogaster
FBpp0290910 E1JJN6 Drosophila melanogaster
FBpp0303222 E1JI13 Drosophila melanogaster
FBpp0303223 M9PFS5 Drosophila melanogaster
FBpp0291300 Q9VNG9 Drosophila melanogaster
FBpp0291301 E1JJ52 Drosophila melanogaster
FBpp0291302 Q8IPP5 Drosophila melanogaster
FBpp0291849 Q8SXX4 Drosophila melanogaster
FBpp0297720 E0R983 Drosophila melanogaster
FBpp0293623 M9NG14 Drosophila melanogaster
FBpp0293621 M9NDT7 Drosophila melanogaster
FBpp0293622 M9NEC1 Drosophila melanogaster
FBpp0305800 M9PI84 Drosophila melanogaster
FBpp0305801 M9PCU3 Drosophila melanogaster
FBpp0278206 Q29FA1 Drosophila pseudoobscura